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Valsartan

Medical and Pharmacy Editor:

Brand Name: Diovan

Generic Name: valsartan

Drug Class: ARBs

What Is Valsartan and How Does It Work?

Valsartan is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and heart attacks (myocardial infarctions, or MI).

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake.

Many patients will require more than one drug to achieve blood pressure goals.

Valsartan is indicated for the treatment of heart failure (NYHA class II-IV).

Valsartan is indicated to reduce cardiovascular mortality in clinically stable patients with left ventricular failure or left ventricular dysfunction following myocardial infarction.

Valsartan is available under the following different brand names: Diovan.

Dosages of Valsartan:

Adult and Pediatric Dosage Forms and Strengths

Tablet

  • 40 mg
  • 80 mg
  • 160 mg
  • 320 mg

Dosage Considerations – Should be Given as Follows:

Hypertension

  • Adult: 80-160 mg/day orally
  • Adult Maintenance: 80-320 mg/day orally
  • Children under 6 years: Safety and efficacy not established
  • Children 6 years and older: 1.3 mg/kg/day orally (not to exceed 40 mg/day); maintenance: 1.3-2.7 mg/kg/day orally (not to exceed 160 mg/day)

Congestive Heart Failure

  • 40 mg orally every 12 hours
  • Maintenance: 40-160 mg orally every 12 hours; not to exceed 320 mg/day

Post-MI Therapy in Left Ventricular Dysfunction

  • May be initiated more than 12 hours after myocardial infarction (MI)
  • 20 mg orally every 12 hours initially, 12 hours after MI, then increased to 40 mg orally every 12 hours within 7 days
  • Maintenance: Titrated to 160 mg orally every 12 hours as tolerated

Administration

  • Although food may decrease absorption (by 40%), manufacturer states drug may be administered without regard to meals
  • Drug may also be given in combination with hydrochlorothiazide (Diovan HCT) or amlodipine (Exforge)

Dose Modification

Renal Impairment

  • CrCl 30 mL/min or greater: No dose adjustment necessary in adults
  • CrCl less than 30 mL/min: Use with caution in adults; not studied in children

Hepatic Impairment

  • Mild to moderate liver impairment: No adjustment necessary; use with caution in liver disease
  • Severe liver impairment: Not studied

Dosing Considerations

  • Generally, adjust dosage monthly (maximal reduction of blood pressure attained after 4 weeks); adjust more aggressively in high-risk patients and patients with comorbidities
Medically Reviewed by a Doctor on 4/13/2017



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