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Zonisamide

Medical and Pharmacy Editor:

Brand Name: Zonegran

Generic Name: Zonisamide

Drug Class: Anticonvulsants, Other

What Is Zonisamide and How Does It Work?

Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy.

Zonisamide is available under the following different brand names: Zonegran.

Dosages of Zonisamide:

Dosage Forms and Strengths

Capsule

  • 25 mg
  • 50 mg
  • 100 mg

Dosage Considerations – Should be Given as Follows:

Partial Seizures

  • Adult: Initial: 100 mg orally once/day
  • Titrate up by 100 mg increments every 2 weeks to no more than 600 mg orally once/day (may divide every 12 hours after 1st week)
  • Adolescents over 16 years: Same as in adults

Weight Loss (Off-label)

  • 100 mg increments every 2 weeks to no more than 600 mg orally once/day (may divide every 12 hours after first week); use 600 mg/day in patients who have not lost at least 5% of their initial body weight

Dosing Modifications

  • Renal impairment: Slower titration and more frequent monitoring advised; not recommended if patient's glomerular filtration rate is less than 50 mL/min
  • Hepatic impairment: Slower titration and more frequent monitoring advised
  • Geriatric: Administer as in adults; initiate dosing at the lower end of the dosing range
  • Children under 16 years: Not recommended
Medically Reviewed by a Doctor on 9/6/2017



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