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Copegus

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Copegus

Overdosage
Contraindications

OVERDOSE

No cases of overdose with COPEGUS have been reported in clinical trials. Hypocalcemia and hypomagnesemia have been observed in persons administered greater than the recommended dosage of ribavirin. In most of these cases, ribavirin was administered intravenously at dosages up to and in some cases exceeding four times the recommended maximum oral daily dose.

CONTRAINDICATIONS

COPEGUS (ribavirin) is contraindicated in:

COPEGUS and PEGASYS combination therapy is contraindicated in patients with:

  • Autoimmune hepatitis.
  • Hepatic decompensation (Child-Pugh score greater than 6; class B and C) in cirrhotic CHC monoinfected patients before treatment [see WARNINGS AND PRECAUTIONS].
  • Hepatic decompensation (Child-Pugh score greater than or equal to 6) in cirrhotic CHC patients coinfected with HIV before treatment [see WARNINGS AND PRECAUTIONS].

Last reviewed on RxList: 3/4/2013
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
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