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There have been cases, some fatal, of Cordarone overdose.
In addition to general supportive measures, the patient's cardiac rhythm and blood pressure should be monitored, and if bradycardia ensues, a β-adrenergic agonist or a pacemaker may be used. Hypotension with inadequate tissue perfusion should be treated with positive inotropic and/or vasopressor agents. Neither Cordarone nor its metabolite is dialyzable.
The acute oral LD50 of amiodarone HCl in mice and rats is greater than 3,000 mg/kg.
Cordarone is contraindicated in patients with cardiogenic shock; severe sinus-node dysfunction, causing marked sinus bradycardia; second-or third-degree atrioventricular block; and when episodes of bradycardia have caused syncope (except when used in conjunction with a pacemaker).
Cordarone is contraindicated in patients with a known hypersensitivity to the drug or to any of its components, including iodine.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 2/6/2014
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