Cordran Lotion (Flurandrenolide Lotion) Drug Overview and Uses for Patients and Caregivers at RxList

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May 27, 2012

Cordran Lotion

Itching »

Itching (itch) facts

The medical term for itching is pruritus.
Infections, bites and stings, infestations, chronic diseases, sun exposure, and dry skin are among the numerous causes of itching.
Anti-itch creams and lotions containing camphor, menthol, phenol, pramoxine (Caladryl, Tronolane), diphenhydramine (Benadryl), or benzocaine can bring relief.
Some cases of itching will respond to corticosteroid medications.
It is best to avoid scratching and itch when possible to avoid worsening of the condition and disruption of the skin that could lead to bacterial infection.
If itching persists with time or worsens, or is associated with skin lesions, consulting a health-care practitioner is advisable.

What is an itch?

Itch is an irritation in the skin that elicits an urge to scratch. Itches are a common problem and can be localized (limited to one area of the body) or gen...

Read the Itching article »

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Cordran Lotion

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Cordran®
Lotion, 0.05% Flurandrenolide Lotion, USP

DRUG DESCRIPTION

Cordran® (flurandrenolide, USP) is a potent corticosteroid intended for topical use. Flurandrenolide occurs as white to off-white, fluffy, crystalline powder and is odorless. Flurandrenolide is practically insoluble in water and in ether. One g dissolves in 72 mL of alcohol and in 10 mL of chloroform. The molecular weight of flurandrenolide is 436.52.

The chemical name of flurandrenolide is Pregn-4-ene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-[(l-methylethylidene)bis (oxy)]-, (6α, 11β, 16α)-; its empirical formula is C₂₄H₃₃FO₆. The structure is as follows:

Cordran®
(flurandrenolide) Structural Formula Illustration

Each mL of Cordran Lotion contains 0.5 mg (1.145 μmol) (0.05%) flurandrenolide in an oil-in-water emulsion base composed of glycerin, cetyl alcohol, stearic acid, glyceryl monostearate, mineral oil, polyoxyl 40 stearate, menthol, benzyl alcohol, and purified water.

Last reviewed on RxList: 8/5/2011
This monograph has been modified to include the generic and brand name in many instances.