Coreg CR (Carvedilol Phosphate Extended-Release) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

Pill Identifier Search

February 9, 2012

Coreg CR

Congestive Heart Failure »

Congestive heart failure facts

Congestive heart failure (CHF) is a condition in which the heart's function as a pump is inadequate to meet the body's needs.

Many disease processes can impair the pumping efficiency of the heart to cause congestive heart failure.

The symptoms of congestive heart failure vary, but can include fatigue, diminished exercise capacity, shortness of breath, and swelling.

The diagnosis of congestive heart failure is based on knowledge of the individual's medical history, a careful physical examination, and selected laboratory tests.

The treatment of congestive heart failure can include lifestyle modifications, addressing potentially reversible factors, medications, heart transplant, and mechanical therapies.

The course of congestive heart failure in any given patient is extremely variable.

What is congestive h...

Read the Congestive Heart Failure article »

« Previous
1
2
3
4
5
6
7
8
9
10
11
12
13
next »

Coreg CR User Reviews >>

Coreg CR

High Blood Pressure (Hypertension) Slideshow Pictures

Take the Salt Quiz!

Lowering Blood Pressure Exercise Tips Slideshow Pictures

font size

COREG CR®
(carvedilol phosphate)

DRUG DESCRIPTION

Carvedilol phosphate is a nonselective β-adrenergic blocking agent with α1-blocking activity. It is (2RS)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol phosphate salt (1:1) hemihydrate. It is a racemic mixture with the following structure:

COREG CR® (carvedilol phosphate) Structural Formula Illustration

Carvedilol phosphate is a white to almost-white solid with a molecular weight of 513.5 (406.5 carvedilol free base) and a molecular formula of C₂₄H₂₆N₂O₄•H₃PO₄•½ H₂O.

COREG CR is available for once-a-day administration as controlled-release oral capsules containing 10, 20, 40, or 80 mg carvedilol phosphate. COREG CR hard gelatin capsules are filled with carvedilol phosphate immediate-release and controlled-release microparticles that are drug-layered and then coated with methacrylic acid copolymers. Inactive ingredients include crospovidone, hydrogenated castor oil, hydrogenated vegetable oil, magnesium stearate, methacrylic acid copolymers, microcrystalline cellulose, and povidone.

What are the possible side effects of carvedilol (Coreg, Coreg CR)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

slow or uneven heartbeats;
feeling light-headed, fainting;
feeling short of breath, even with mild exertion;
swelling of your ankles or feet;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing...

Read All Potential Side Effects and See Pictures of Coreg CR »

What are the precautions when taking carvedilol phosphate extended-release (Coreg CR)?

Before taking carvedilol, tell your doctor or pharmacist if you are allergic to it; or if you have had a serious reaction to other beta blockers (e.g., propranolol); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: asthma, certain types of heart rhythm problems (sinus bradycardia, sick sinus syndrome, second- or third-degree atrioventricular block), severe heart failure.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, serious...

Read All Potential Precautions of Coreg CR »

Last reviewed on RxList: 8/19/2011
This monograph has been modified to include the generic and brand name in many instances.