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Coreg CR

Last reviewed on RxList: 12/25/2016
Coreg CR Patient Information Including Side Effects

Brand Names: Coreg, Coreg CR

Generic Name: carvedilol (Pronunciation: KAR ve dil ole)

What is carvedilol (Coreg CR)?

Carvedilol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

Carvedilol is used to treat heart failure and hypertension (high blood pressure). It is also used after a heart attack that has caused your heart not to pump as well.

Carvedilol may also be used for purposes not listed in this medication guide.

What are the possible side effects of carvedilol (Coreg CR)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • feeling like you might pass out;
  • slow or uneven heartbeats;
  • chest pain, dry cough, wheezing, chest tightness, trouble breathing;
  • feeling short of breath, even with mild exertion;
  • swelling, rapid weight gain;
  • numbness or cold feeling in your hands and feet;
  • loss of bladder control;
  • pale skin, feeling light-headed, rapid heart rate, trouble concentrating;
  • high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss); or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • dizziness, drowsiness;
  • nausea, vomiting, diarrhea;
  • dry eyes;
  • feeling weak or tired;
  • joint pain;
  • cough; or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Coreg CR (carvedilol phosphate extended-release) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about carvedilol (Coreg CR)?

You should not take this medication if you are allergic to carvedilol, or if you have asthma, bronchitis, emphysema, severe liver disease, or a serious heart condition such as heart block, sick sinus syndrome, or slow heart rate (unless you have a pacemaker).

If you need surgery, tell the surgeon ahead of time that you are using carvedilol. You may need to stop using the medicine for a short time.

Do not stop taking carvedilol without first talking to your doctor. Stopping suddenly may make your condition worse.

Avoid drinking alcohol within 2 hours before or after taking extended-release carvedilol (Coreg CR). Also avoid taking medicines or other products that might contain alcohol. Alcohol may cause the carvedilol in Coreg CR to be released too quickly into the body.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Coreg CR Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking carvedilol (Coreg CR)?

You should not take this medication if you are allergic to carvedilol, or if you have:

  • asthma, bronchitis, emphysema;
  • severe liver disease; or
  • a serious heart condition such as heart block, sick sinus syndrome, or slow heart rate (unless you have a pacemaker).

To make sure you can safely take carvedilol, tell your doctor if you have any of these other conditions:

  • diabetes (taking carvedilol can make it harder for you to tell when you have low blood sugar);
  • angina (chest pain);
  • low blood pressure;
  • kidney disease;
  • liver disease;
  • a thyroid disorder;
  • pheochromocytoma (tumor of the adrenal gland);
  • circulation problems (such as Raynaud's syndrome); or
  • a history of allergies.

FDA pregnancy category C. It is not known whether carvedilol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether carvedilol passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking carvedilol.

How should I take carvedilol (Coreg CR)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Carvedilol works best if you take it with food.

Take carvedilol at the same time every day. Do not skip doses or stop taking carvedilol without first talking to your doctor. Stopping suddenly may make your condition worse.

You may open the carvedilol capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Discard the empty capsule.

If you are switched from carvedilol tablets to carvedilol extended-release capsules (Coreg CR), your daily total dose of this medicine may be higher or lower than before. Older adults may be more likely to become dizzy or feel faint when switching from tablets to extended-release capsules. Follow your doctor's instructions.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Your blood pressure will need to be checked often. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using carvedilol. You may need to stop using the medicine for a short time.

Carvedilol can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using carvedilol before surgery unless your surgeon tells you to.

Carvedilol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.

Store at room temperature away from moisture and heat.

Coreg CR Patient Information including If I Miss a Dose

What happens if I miss a dose (Coreg CR)?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Coreg CR)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, and seizure (convulsions).

What should I avoid while taking carvedilol (Coreg CR)?

Carvedilol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid drinking alcohol within 2 hours before or after taking extended-release carvedilol (Coreg CR). Also avoid taking medicines or other products that might contain alcohol. Alcohol may cause the carvedilol in Coreg CR to be released too quickly into the body. Check the labels of any prescription or over-the-counter medicines you take to see if they contain alcohol (also called ethanol).

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What other drugs will affect carvedilol (Coreg CR)?

Many drugs can interact with carvedilol. Below is just a partial list. Tell your doctor if you are using:

  • allergy treatments (or if you are undergoing allergy skin-testing);
  • cimetidine (Tagamet);
  • cyclosporine (Gengraf, Neoral, Sandimmune);
  • fluconazole (Diflucan);
  • insulin or oral diabetes medication;
  • rifampin (Rifadin, Rifater, Rifamate);
  • an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), bupropion (Wellbutrin, Zyban), clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem), imipramine (Tofranil), paroxetine (Paxil), or sertraline (Zoloft);
  • heart or blood pressure medicine such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta), clonidine (Catapres), diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), reserpine, verapamil (Calan, Covera, Isoptin, Verelan), and others;
  • a heart rhythm medication such as amiodarone (Cordarone, Pacerone), digoxin (digitalis, Lanoxin), flecainide (Tambocor), propafenone (Rythmol), or quinidine (Quin-G);
  • HIV or AIDS medicine such as delavirdine (Rescriptor) or ritonavir (Norvir, Kaletra);
  • an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate);
  • medicine to prevent or treat nausea and vomiting, such as metoclopramide (Reglan) or promethazine (Pentazine, Phenergan, Anergan, Antinaus);
  • medicine to treat psychiatric disorders, such as aripiprazole (Abilify), chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), perphenazine (Trilafon), or thioridazine (Mellaril); or
  • a narcotic such as methadone (Methadose, Diskets, Dolophine) or propoxyphene (Daron, Darvocet).

This list is not complete and there are many other drugs that can interact with carvedilol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about carvedilol.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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