Corgard
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Corgard
INDICATIONS
Angina Pectoris
CORGARD (nadolol) is indicated for the long-term management of patients with angina pectoris.
Hypertension
CORGARD (nadolol) is indicated in the management of hypertension; it may be used alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.
DOSAGE AND ADMINISTRATION
DOSAGE MUST BE INDIVIDUALIZED. CORGARD (NADOLOL) MAY BE ADMINISTERED WITHOUT REGARD TO MEALS.
Angina Pectoris
The usual initial dose is 40 mg CORGARD (nadolol) once daily. Dosage may be gradually increased in 40 to 80 mg increments at 3 to 7 day intervals until optimum clinical response is obtained or there is pronounced slowing of the heart rate. The usual maintenance dose is 40 or 80 mg administered once daily. Doses up to 160 or 240 mg administered once daily may be needed. The usefulness and safety in angina pectoris of dosage exceeding 240 mg per day have not been established. If treatment is to be discontinued, reduce the dosage gradually over a period of one to two weeks (see WARNINGS).
Hypertension
The usual initial dose is 40 mg CORGARD (nadolol) once daily, whether it is used alone or in addition to diuretic therapy. Dosage may be gradually increased in 40 to 80 mg increments until optimum blood pressure reduction is achieved. The usual maintenance dose is 40 or 80 mg administered once daily. Doses up to 240 or 320 mg administered once daily may be needed.
Dosage Adjustment in Renal Failure
Absorbed nadolol is excreted principally by the kidneys and, although nonrenal elimination does occur, dosage adjustments are necessary in patients with renal impairment. The following dose intervals are recommended:
| Creatinine Clearance (mL/min/1.73m²) | Dosage Interval (hours) |
| > 50 | 24 |
| 31–50 | 24–36 |
| 10–30 | 24–48 |
| < 10 | 40–60 |
HOW SUPPLIED
CORGARD Tablets (Nadolol Tablets USP)
20 mg tablets in bottles of 100 (NDC 60793–800–01),
40 mg
tablets in bottles of 100 (NDC 60793–801–01) and
80 mg tablets
in bottles of 100 (NDC 60793–802–01).
All tablets are scored (bisect bar) and easy to break. Tablet identification numbers: 20 mg, 232; 40 mg, 207; and 80 mg, 241.
Storage
Store at room temperature; avoid excessive heat. Protect from light. Keep bottle tightly closed.
February 2011. Manufactured and Distributed by: King Pharmaceuticals, Inc., Bristol, TN 37620
Last reviewed on RxList: 7/8/2011
This monograph has been modified to include the generic and brand name in many instances.
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