April 29, 2017
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"The U.S. Food and Drug Administration today approved Corlanor (ivabradine) to reduce hospitalization from worsening heart failure.

Corlanor is approved for use in certain people who have long-lasting (chronic) heart failure caused by the lo"...



(ivabradine) Tablets


Carlanor (ivabradine) is a hyperpolarization-activated cyclic nucleotide-gated channel blocker that reduces the spontaneous pacemaker activity of the cardiac sinus node by selectively inhibiting the If-current(If),resulting heart rate reducing with no effects on ventricular repolarization and no effects on myocardial contractility.

The chemical name for ivabradine is 3-(3-{[((7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-y1)methy1]methy1 amino}propy1)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one,hydrochloride.The molecular formula is C27H36N2O5,HCl,and the molecular weight(free base+HCl)is 505.1(468.6+36.5).The chemical Structure of ivabradine is shown in Figure 1.

Figure 1.Chemical Structure of Ivabradine

Carlanor®(ivabradine) Structural Formula Illustration

Corlanor tablets are formulated as salmon-colored, film-coated tablets for oral administration in strengths of 5 mg and 7.5 mg ivabradine as the free base equivalent.

Inactive Ingredients


Lactose monohydrate, maize starch, maltodextrin, magnesium strearate, colloidal silicon dioxide

Film Coating

Hypromellose, titanium dioxide, glycerol, magnesium stearate, polyethylene glycol 6000, yellow iron oxide, red iron oxide

Last reviewed on RxList: 4/11/2017
This monograph has been modified to include the generic and brand name in many instances.

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