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Cortisporin Ophthalmic Ointment

"Glaucoma is a group of diseases that damage the optic nerve, a cable at the back of each eye that connects it to the brain. It affects more than 2.7 million people in the United States and more than 60 million worldwide. There are many forms of t"...

Cortisporin Ophthalmic Ointment

CORTISPORIN® Ophthalmic Ointment
(neomycin and polymyxin B sulfates, bacitracin zinc, and hydrocortisone) Ophthalmic Ointment, USP

DRUG DESCRIPTION

CORTISPORIN® Ophthalmic Ointment (neomycin and polymyxin b sulfates, bacitracin zinc, and hydrocortisone ophthalmic ) (neomycin and polymyxin B sulfates, bacitracin zinc, and hydrocortisone ophthalmic ointment) is a sterile antimicrobial and anti- inflammatory ointment for ophthalmic use. Each gram contains: neomycin sulfate equivalent to 3.5 mg neomycin base, polymyxin B sulfate equivalent to 10,000 polymyxin B units, .bacitracin zinc equivalent to 400 bacitracin units, hydrocortisone 10 mg (1 %), and white petrolatum, q.s.

Neomycin sulfate is the sulfate salt of neomycin B and C, which are produced by the growth of Streptomyces fradiae Waksman (Fam. Streptomycetaceae ). It has a potency equivalent of not less than 600 g of neomycin standard per mg, calculated on an anhydrous basis. The structural formulae are:

Neomycin sulfate structural formula illustration

Polymyxin B sulfate is the sulfate salt of polymyxin B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae). It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formulae are:

Polymyxin B sulfate structural formula illustration

Bacitracin zinc is the zinc salt of bacitracin, a mixture of related cyclic polypeptides (mainly bacitracin A) produced by the growth of an organism of the licheniformis group of Bacillus subtilis var Tracy. It has a potency of not less than 40 bacitracin units per mg. The structural formula is:

Bacitracin zinc structural formula illustration

Hydrocortisone, 11β, 17, 21-trihydroxypregn-4-ene-3, 20-dione, is an anti-inflammatory hormone. Its structural formula is:

Hydrocortisone structural formula illustration

Last reviewed on RxList: 4/30/2008
This monograph has been modified to include the generic and brand name in many instances.

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