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(cosyntropin) 0.25 mg Injection, USP 1ml Vial


CORTROSYN™ (cosyntropin) for Injection is a sterile lyophilized powder in vials containing 0.25 mg of CORTROSYN™ and 10 mg of mannitol to be reconstituted with 1 mL of 0.9% Sodium Chloride Injection, USP. Administration is by intravenous or intramuscular injection. Cosyntropin is a 1 – 24 corticotropin, a synthetic subunit of ACTH. It is an open chain polypeptide containing, from the N terminus, the first 24 of the 39 amino acids of natural ACTH. The sequence of amino acids in the 1 – 24 compound is as follows:

Ser 1 Tyr 2 Ser 3 Met 4 Glu 5 His 6 Phe 7 Arg 8 Trp 9 Gly 10 Lys 11
Pro 12 Val 13 Gly 14 Lys 15 Lys 16 Arg 17 Arg 18 Pro 19 Val 20 Lys 21 Val 22
Tyr 23 Pro 24                  

What are the precautions when taking cosyntropin (Cortrosyn)?

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Last reviewed on RxList: 5/17/2016
This monograph has been modified to include the generic and brand name in many instances.

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