Cortrosyn Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Cortrosyn (cosyntropin) for Injection is used to diagnose adrenal gland problems (e.g., Addison's disease, insufficiency due to corticosteroid use, pituitary tumor). It is a man-made portion of a certain natural substance made by the body (ACTH). This medication is available in generic form. Common side effects include minor irritation at the injection site (e.g., redness, swelling).

When given as an intravenous infusion, Cortrosyn in a 0.25 mg dose may be added to glucose or saline solutions and given at the rate of approximately 40 micrograms per hour over a 6-hour period. Cortrosyn may interact with cortisone, estrogen, hydrocortisone, spironolactone, or diuretics. Tell your doctor all medications and supplements you use. During pregnancy, Cortrosyn should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Cortrosyn (cosyntropin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Cortrosyn Overview - Patient Information: Side Effects

SIDE EFFECTS: Consult your pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Cortrosyn (Cosyntropin)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Cortrosyn FDA Prescribing Information: Side Effects
(Adverse Reactions)


Since CORTROSYN™ (cosyntropin) for Injection is intended for diag-nostic and not therapeutic use, adverse reactions other than a rare hypersensitivity reaction are not anticipated. A rare hypersensitivity reaction usually associated with a pre-existing allergic disease and/or a previous reaction to natural ACTH is possible. Symptoms may include slight whealing with splotchy erythema at the injection site. There have been rare reports of anaphylactic reaction. The following adverse reactions have been reported in patients after the admin-istration of CORTROSYN™ (cosyntropin) and the association has been neither confirmed nor refuted:

Read the entire FDA prescribing information for Cortrosyn (Cosyntropin)


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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