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Corvert

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Corvert

Corvert®
(ibutilide fumarate) Injection

For intravenous infusion only

DRUG DESCRIPTION

CORVERT Injection (ibutilide fumarate injection) is an antiarrhythmic drug with predominantly class III (cardiac action potential prolongation) properties according to the Vaughan Williams Classification. Each milliliter of CORVERT Injection contains 0.1 mg of ibutilide fumarate (equivalent to 0.087 mg ibutilide free base), 0.189 mg sodium acetate trihydrate, 8.90 mg sodium chloride, hydrochloric acid to adjust pH to approximately 4.6, and Water for Injection.

CORVERT (ibutilide fumarate injection) Injection is an isotonic, clear, colorless, sterile aqueous solution. Ibutilide fumarate has one chiral center, and exists as a racemate of the (+) and (-) enantiomers.

The chemical name for ibutilide fumarate is Methanesulfonamide, N-{4-{4-(ethylheptylamino)-1-hydroxybutyl}phenyl}, (+) (-), (E)-2-butenedioate (1:0.5) (hemifumarate salt). Its molecular formula is C22H38N2O5S, and its molecular weight is 442.62.

Ibutilide fumarate is a white to off-white powder with an aqueous solubility of over 100 mg/mL at pH 7 or lower.

The structural formula is represented below:

Corvert® (ibutilide fumarate) Structural Formula Illustration

What are the possible side effects of ibutilide (Corvert)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Your caregivers will watch you closely with a heart monitor and other medical devices to check for serious side effects. Tell your caregivers if you feel short of breath or like you might pass out.

Less serious side effects may include:

  • headache; or
  • nausea.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You...

Read All Potential Side Effects and See Pictures of Corvert »

Last reviewed on RxList: 6/25/2008
This monograph has been modified to include the generic and brand name in many instances.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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