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Corzide

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Corzide

CORZIDE®
(nadolol and bendroflumethiazide) Tablets

Corzide

DRUG DESCRIPTION

CORZIDE (Nadolol and Bendroflumethiazide Tablets) for oral administration combines two antihypertensive agents: CORGARD® (nadolol), a nonselective beta-adrenergic blocking agent, and NATURETIN® (bendroflumethiazide), a thiazide diuretic-antihypertensive. Formulations: 40 mg and 80 mg nadolol per tablet combined with 5 mg bendroflumethiazide. Inactive ingredients: cellulose, colorant (FD&C Blue No. 2), lactose, magnesium stearate, povidone, sodium starch glycolate, and starch.

Nadolol

Nadolol is a white crystalline powder. It is freely soluble in ethanol, soluble in hydrochloric acid, slightly soluble in water and in chloroform, and very slightly soluble in sodium hydroxide. Nadolol is designated chemically as 1-(tert-butylamino)-3-{(5,6,7,8-tetrahydro-cis-6,7dihydroxy-1-naphthyl)oxy}-2-propanol. Structural formula:

Nadolol Structural Formula Illustration

C17H27NO4        MW 309.40 CAS-42200-33-9

Bendroflumethiazide

Bendroflumethiazide is a white crystalline powder. It is soluble in alcohol and in sodium hydroxide, and insoluble in hydrochloric acid, water, and chloroform. Bendroflumethiazide is designated chemically as 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7sulfonamide 1,1-dioxide. Structural formula:

Bendroflumethiazide Structural Formula Illustration

C15H14F3N3O4S2         MW 421.41 CAS-73-48-3

What are the possible side effects of bendroflumethiazide and nadolol (Corzide 40/5, Corzide 80/5)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • swelling, rapid weight gain, feeling short of breath, even with mild exertion;
  • fast, slow, or uneven heartbeat;
  • easy bruising or bleeding;
  • numbness or tingly feeling in your hands or feet;
  • feeling weak, drowsy, restless, or...

Read All Potential Side Effects and See Pictures of Corzide »

What are the precautions when taking nadolol and bendroflumethiazide (Corzide)?

Before taking this product, tell your doctor or pharmacist if you are allergic to nadolol or bendroflumethiazide; or to other thiazides (such as hydrochlorothiazide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems (such as a slow heartbeat, second- or third-degree atrioventricular block, sick sinus syndrome), an inability to make urine (anuria), breathing problems (such as asthma, chronic bronchitis, emphysema).

Before using this medication, tell your doctor...

Read All Potential Precautions of Corzide »

Last reviewed on RxList: 7/25/2013
This monograph has been modified to include the generic and brand name in many instances.

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Corzide - User Reviews

Corzide User Reviews

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Here is a collection of user reviews for the medication Corzide sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Hypertension

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