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Corzide Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Corzide (nadolol and bendroflumethiazide) is a combination beta-blocker and diuretic used to treat high blood pressure (hypertension). This medication is available in generic form. Common side effects include dizziness, lightheadedness, slow heartbeat, tiredness, nausea, and vomiting. Decreased sexual ability has been reported infrequently.
Dosing of Corzide is individualized. The initial dose of Corzide may be 40 mg/5 mg tablet once daily. Corzide may interact with narcotics, barbiturates, amphotericin B, blood thinners, calcium supplements, colestipol, cholestyramine, diazoxide, digoxin, gout medications, insulin or oral diabetes medicines, lithium, MAO inhibitors, steroids, other heart or blood pressure medications, or NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications and supplements you use. During pregnancy, Corzide should be used only if prescribed. It may harm a fetus. This medication passes into breast milk. Nadolol may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.
Our Corzide (nadolol and bendroflumethiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Corzide in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:
- swelling, rapid weight gain, feeling short of breath, even with mild exertion;
- fast, slow, or uneven heartbeat;
- easy bruising or bleeding;
- numbness or tingly feeling in your hands or feet;
- feeling weak, drowsy, restless, or light-headed;
- nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions);
- increased urination, leg discomfort, muscle pain or weakness or limp feeling;
- urinating less than usual or not at all;
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
- upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
- diarrhea, constipation, upset stomach;
- dizziness, spinning sensation;
- blurred vision;
- depressed mood; or
- ringing in your ears.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Corzide (Nadolol and Bendroflumethiazide)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Corzide Overview - Patient Information: Side Effects
Dizziness, lightheadedness, slow heartbeat, tiredness, nausea, and vomiting may occur. Decreased sexual ability has been reported infrequently. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
This product may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
The bendroflumethiazide in this product may cause your body to lose too much water and salt (dehydration). Tell your doctor immediately if you have any of these unlikely but serious symptoms of dehydration: very dry mouth, extreme thirst, muscle cramps/weakness, fast heartbeat, severe dizziness, confusion, fainting, seizures.
Tell your doctor immediately if any of these unlikely but serious side effects occur: very slow/irregular heartbeat, new or worsening symptoms of heart failure (such as swelling ankles/feet, severe tiredness, shortness of breath, unexplained/sudden weight gain), mental/mood changes (such as depression, mood swings), toe/joint pain.
Tell your doctor immediately if any of these rare but very serious side effects occur: trouble breathing, blue fingers/toes, easy bruising/bleeding, signs of infection (such as fever, persistent sore throat), yellowing eyes/skin, persistent nausea/vomiting, severe stomach/abdominal pain, dark urine, change in the amount of urine (not including the normal increase in urine when you first start this drug).
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Corzide (Nadolol and Bendroflumethiazide)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Corzide FDA Prescribing Information: Side Effects
Most adverse effects have been mild and transient and have rarely required withdrawal of therapy.
Cardiovascular-Bradycardia with heart rates of less than 60 beats per minute occurs commonly, and heart rates below 40 beats per minute and/or symptomatic bradycardia were seen in about 2 of 100 patients. Symptoms of peripheral vascular insufficiency, usually of the Raynaud type, have occurred in approximately 2 of 100 patients. Cardiac failure, hypotension, and rhythm/conduction disturbances have each occurred in about 1 of 100 patients. Single instances of first degree and third degree heart block have been reported; intensification of AV block is a known effect of beta-blockers (see also CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS).
Central Nervous System-Dizziness or fatigue has been reported in approximately 2 of 100 patients; paresthesias, sedation, and change in behavior have each been reported in approximately 6 of 1000 patients.
Miscellaneous-Each of the following has been reported in 1 to 5 of 1000 patients: rash; pruritus; headache; dry mouth, eyes, or skin; impotence or decreased libido; facial swelling; weight gain; slurred speech; cough; nasal stuffiness; sweating; tinnitus; blurred vision. Reversible alopecia has been reported infrequently.
The following adverse reactions have been reported in patients taking nadolol and/or other betaadrenergic blocking agents, but no causal relationship to nadolol has been established.
Central Nervous System-Reversible mental depression progressing to catatonia; visual disturbances; hallucinations; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability with slightly clouded sensorium, and decreased performance on neuropsychometrics.
Allergic-Fever combined with aching and sore throat; laryngospasm; respiratory distress.
Miscellaneous-Pemphigoid rash; hypertensive reaction in patients with pheochromocytoma; sleep disturbances; Peyronie's disease.
The oculomucocutaneous syndrome associated with the beta-blocker practolol has not been reported with nadolol.
Gastrointestinal-Nausea, vomiting, cramping and anorexia are not uncommon; diarrhea, constipation, gastric irritation, abdominal bloating, jaundice (intrahepatic cholestatic jaundice), hepatitis, and sialadenitis occasionally occur; and pancreatitis has been reported.
Dermatologic-Hypersensitivity-Purpura, exfoliative dermatitis, pruritus, ecchymosis, urticaria, necrotizing angiitis (vasculitis, cutaneous vasculitis), respiratory distress including pneumonitis, fever, and anaphylactic reactions occasionally occur; photosensitivity and rash have been reported.
Cardiovascular-Orthostatic hypotension may occur and may be potentiated by coadministration with certain other drugs (e.g., alcohol, barbiturates, narcotics, other antihypertensive medications, etc.; see DRUG INTERACTIONS).
Other-Muscle spasm, weakness, or restlessness is not uncommon; hyperglycemia, glycosuria, metabolic acidosis in diabetic patients, hyperuricemia, allergic glomerulonephritis, and transient blurred vision occasionally occur.
Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.
Read the entire FDA prescribing information for Corzide (Nadolol and Bendroflumethiazide)
Additional Corzide Information
Corzide - User Reviews
Corzide User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.