"The US Food and Drug Administration (FDA) has approved ranibizumab injection (Lucentis, Genentech) in a prefilled syringe, the company has announced.
Like the Lucentis 0.5 mg vial, the 0.5 mg prefilled syringe (PFS) is approved"...
Symptoms consistent with systemic administration of beta-blockers or carbonic anhydrase inhibitors may occur, including electrolyte imbalance, development of an acidotic state, dizziness, headache, shortness of breath, bradycardia, bronchospasm, cardiac arrest and possible central nervous system effects. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored. [See ADVERSE REACTIONS]
A study of patients with renal failure showed that timolol did not dialyze readily.
COSOPT is contraindicated in patients with bronchial asthma, a history of bronchial asthma, or severe chronic obstructive pulmonary disease [see WARNINGS AND PRECAUTIONS].
Sinus Bradycardia, AV Block, Cardiac Failure, Cardiogenic Shock
COSOPT is contraindicated in patients with sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, and cardiogenic shock [see WARNINGS AND PRECAUTIONS].
COSOPT is contraindicated in patients who are hypersensitive to any component of this product [see WARNINGS AND PRECAUTIONS].This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 11/4/2016
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