"The U.S. Food and Drug Administration today approved the Argus II Retinal Prosthesis System, the first implanted device to treat adult patients with advanced retinitis pigmentosa (RP). The device, which includes a small video camera, transmitter "...
There are no human data available on overdosage with COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) .
Symptoms consistent with systemic administration of beta-blockers or carbonic anhydrase inhibitors may occur, including electrolyte imbalance, development of an acidotic state, dizziness, headache, shortness of breath, bradycardia, bronchospasm, cardiac arrest and possible central nervous system effects. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored (see also ADVERSE REACTIONS).
A study of patients with renal failure showed that timolol did not dialyze readily.
COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is contraindicated in patients with (1) bronchial asthma; (2) a history of bronchial asthma; (3) severe chronic obstructive pulmonary disease (see WARNINGS); (4) sinus bradycardia; (5) second or third degree atrioventricular block; (6) overt cardiac failure (see WARNINGS); (7) cardiogenic shock; or (8) hypersensitivity to any component of this product.
Last reviewed on RxList: 7/20/2010
This monograph has been modified to include the generic and brand name in many instances.
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