"Almost all of the 41 million estimated contact lens wearers in the United States may be engaging in at least one behavior known to increase their risk of eye infections, according to a report published today by the Centers for Disease Control and"...
There are no human data available on overdosage with COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) .
Symptoms consistent with systemic administration of beta-blockers or carbonic anhydrase inhibitors may occur, including electrolyte imbalance, development of an acidotic state, dizziness, headache, shortness of breath, bradycardia, bronchospasm, cardiac arrest and possible central nervous system effects. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored (see also ADVERSE REACTIONS).
A study of patients with renal failure showed that timolol did not dialyze readily.
COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is contraindicated in patients with (1) bronchial asthma; (2) a history of bronchial asthma; (3) severe chronic obstructive pulmonary disease (see WARNINGS); (4) sinus bradycardia; (5) second or third degree atrioventricular block; (6) overt cardiac failure (see WARNINGS); (7) cardiogenic shock; or (8) hypersensitivity to any component of this product.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 7/20/2010
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