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Coumadin

"Aug. 31, 2011 (Paris) -- The anti-clotting drug warfarin is safe and beneficial for people aged 80 and over, according to a new report.

But the drug is being prescribed to fewer than half of older people with a heart condition that pu"...

Coumadin

Coumadin Side Effects Center

Medical Editor: Charles Patrick Davis, MD, PhD

Coumadin (warfarin) is a blood anticoagulant that inhibits the function of Vitamin K dependent coagulation. Coumadin is available as a generic, termed warfarin or warfarin sodium. Coumadin is used to inhibit the coagulation of blood to reduce or prevent the chance of developing heart attacks (myocardial infarctions), strokes, and venous and other blood clots (deep venous thromboses, pulmonary embolisms and thrombi produced with atrial fibrillation). Coumadin is also used to treat these conditions if they develop. The most common side effects of this drug are easy bruising and bleeding.

Coumadin has a wide range of tablets: 2, 2.5, 3, 4, 5, 6, 7.5 and 10 mg tablets are available. An injectable form of the drug (5 mg) is also available. The dose of Coumadin is determined in each individual by administering a trial dose and ten measuring the patient's INR (International Normalized Ratio), a lab test that is standardized by the WHO (world Health Organization) and recognized worldwide. Therapeutic ranges for this test are between 2.0 to 3.0 when a patient is taking Coumadin. INR levels below 2 may allow easier blood clotting to occur while levels above 3 may cause excessive tendency for the patient to bleed. Several different Coumadin doses and INR tests (over 1-4 weeks) are usually necessary to establish a relatively stable and therapeutic INR level in each individual. Unfortunately, there are at least 60 different drugs that may increase or decrease the body's ability to utilize Coumadin any the majority of people that need Coumadin are often require one or more of these drugs; this situation also is why each Coumadin dose is individualized. The major risk factor with Coumadin is hemorrhage. Small emboli may occasionally be released while on Coumadin, causing "purple toes;" although this may be reversible, a few patients may develop gangrene. Pregnant women should not be given Coumadin; lactating women may need to be closely monitored and their breastfed infants should have their INR checked, according to some investigators. Although Coumadin has been used in pediatric patients to prevent clot formations, children under 18 have not been well studied with this drug and some investigators suggest achieving stable INR levels seems more difficult in the pediatric population.

Our Coumadin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Coumadin in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using warfarin and call your doctor at once if you have a serious side effect such as:

  • pain, swelling, hot or cold feeling, skin changes, or discoloration anywhere on your body;
  • sudden and severe leg or foot pain, foot ulcer, purple toes or fingers;
  • sudden headache, dizziness, or weakness;
  • unusual bleeding (nose, mouth, vagina, or rectum), bleeding from wounds or needle injections, any bleeding that will not stop;
  • easy bruising, purple or red pinpoint spots under your skin;
  • blood in your urine, black or bloody stools, coughing up blood or vomit that looks like coffee grounds;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • dark urine, jaundice (yellowing of the skin or eyes);
  • pain in your stomach, back, or sides;
  • urinating less than usual or not at all;
  • numbness or muscle weakness; or
  • any illness with diarrhea, fever, chills, body aches, or flu symptoms.

Less serious side effects may include:

  • nausea, vomiting, mild stomach pain;
  • bloating, gas; or
  • altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Coumadin (Warfarin Sodium) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Coumadin Overview - Patient Information: Side Effects

SIDE EFFECTS: Nausea, loss of appetite, or stomach/abdominal pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication can cause serious bleeding if it affects your blood clotting proteins too much (shown by unusually high INR lab results). Even if your doctor stops your medication, this risk of bleeding can continue for up to a week. Tell your doctor right away if you have any signs of serious bleeding, including: unusual pain/swelling/discomfort, unusual/easy bruising, prolonged bleeding from cuts or gums, persistent/frequent nosebleeds, unusually heavy/prolonged menstrual flow, pink/dark urine, coughing up blood, vomit that is bloody or looks like coffee grounds, severe headache, dizziness/fainting, unusual or persistent tiredness/weakness, bloody/black/tarry stools, chest pain, shortness of breath, difficulty swallowing.

Tell your doctor right away if any of these unlikely but serious side effects occur: persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes/skin.

This drug rarely has caused very serious (possibly fatal) problems if its effects lead to small blood clots (usually at the beginning of treatment). This can lead to severe skin/tissue damage that may require surgery or amputation if left untreated. Patients with certain blood conditions (protein C or S deficiency) may be at greater risk. Get medical help right away if any of these rare but serious side effects occur: painful/red/purplish patches on the skin (such as on the toe, breast, abdomen), change in the amount of urine, vision changes, confusion, slurred speech, weakness on one side of the body.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Coumadin (Warfarin Sodium)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Coumadin FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

The following serious adverse reactions to COUMADIN are discussed in greater detail in other sections of the labeling:

Other adverse reactions to COUMADIN include:

  • Immune system disorders: hypersensitivity/allergic reactions (including urticaria and anaphylactic reactions)
  • Vascular disorders: vasculitis
  • Hepatobiliary disorders: hepatitis, elevated liver enzymes. Cholestatic hepatitis has been associated with concomitant administration of COUMADIN and ticlopidine.
  • Gastrointestinal disorders: nausea, vomiting, diarrhea, taste perversion, abdominal pain, flatulence, bloating
  • Skin disorders: rash, dermatitis (including bullous eruptions), pruritus, alopecia
  • Respiratory disorders: tracheal or tracheobronchial calcification
  • General disorders: chills

Read the entire FDA prescribing information for Coumadin (Warfarin Sodium) »

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Coumadin - User Reviews

Coumadin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Coumadin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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