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Cranberry

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Are there any interactions with medications?



Atorvastatin (Lipitor)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Atorvastatin (Lipitor) is a medication used for lowering cholesterol. The body breaks down atorvastatin (Lipitor) to get rid of it. Cranberry might decrease how quickly the body breaks down atorvastatin (Lipitor). Drinking cranberry juice while taking these medications might increase the effects and side effects of atorvastatin (Lipitor). Avoid drinking large amounts of cranberry juice if you are taking atorvastatin (Lipitor).



Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Cranberry might decrease how quickly the liver breaks down some medications. Taking cranberry along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking cranberry, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.



Nifedipine (Procardia)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Cranberry might decrease how quickly the body breaks down some medications that are broken down by the liver, including nifedipine (Procardia). In theory, drinking cranberry juice while taking nifedipine might increase the effects and side effects of nifedipine (Procardia).



Warfarin (Coumadin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Warfarin (Coumadin) is used to slow blood clotting. Cranberry might increase how long warfarin (Coumadin) is in the body, and increase the chances of bruising and bleeding. But, research in this area is not consistent. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.



Diclofenac (Voltaren, others)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Cranberry might decrease how quickly the body breaks down some medications that are broken down by the liver, including diclofenac (Voltaren, others). In theory, drinking cranberry juice while taking diclofenac might increase the effects and side effects of diclofenac.



Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Some research suggests that cranberry might decrease how quickly the liver breaks down some medications. Taking cranberry along with some medications that are broken down by the liver can increase the effects and side effects of some medications. But, research in this area is not consistent. Before taking cranberry, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.

Dosing considerations for Cranberry.

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:
  • For preventing urinary tract infections (UTIs): Capsules or tablets containing 200-500 mg of dried cranberry taken once or twice daily have been used. Drinking cranberry juice 120-300 mL daily has also been used.

CHILDREN

BY MOUTH:
  • For preventing urinary tract infections (UTIs): 50 mL of a cranberry and lingonberry concentrate taken daily for 6 months has been used. Also, 5 mL/kg of cranberry juice taken daily for 6 months has been used.

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