"By Kelli Miller
WebMD Health News
Reviewed by Brunilda Nazario, MD
March 5, 2015 -- Babies created from the DNA of two women and a man could be born as early as next year. Last month, the United Kingdom cleared the way for fert"...
Crinone Patient Information Including Side Effects
Brand Names: Crinone, Endometrin, FIRST-Progesterone VGS 100, FIRST-Progesterone VGS 200, FIRST-Progesterone VGS 25, FIRST-Progesterone VGS 400, FIRST-Progesterone VGS 50, Menopause Formula Progesterone, Prochieve
Generic Name: progesterone vaginal (Pronunciation: proe JESS te role VAJ in ul)
- What is progesterone vaginal (Crinone)?
- What are the possible side effects of progesterone vaginal?
- What is the most important information I should know about progesterone vaginal?
- What should I discuss with my healthcare provider before using progesterone vaginal?
- How should I use progesterone vaginal?
- What happens if I miss a dose?
- What happens if I overdose?
- What should I avoid while using progesterone vaginal?
- What other drugs will affect progesterone vaginal?
- Where can I get more information?
What is progesterone vaginal (Crinone)?
Progesterone is a female hormone important for ovulation and menstruation. Progesterone causes changes in the lining of your uterus, making it easier for a fertilized egg to attach to the uterus at the beginning of pregnancy. Progesterone then helps your body maintain the pregnancy.
Progesterone vaginal is used in fertility treatment as part of Assisted Reproductive Technology (ART) for women unable to get pregnant due to a lack of natural progesterone in the body.
Progesterone vaginal is also used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body.
This medication also prevents overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.
Progesterone vaginal may also be used for other purposes not listed in this medication guide.
What are the possible side effects of progesterone vaginal?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- sudden headache, numbness or weakness (especially on one side of the body), shortness of breath, or problems with vision, speech, or balance;
- chest pain or heavy feeling, pain spreading to the arm or shoulder;
- pain or swelling in one or both legs;
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- swelling in your hands, ankles, or feet;
- fever, chills, body aches, flu symptoms;
- a breast lump; or
- symptoms of depression (sleep problems, weakness, mood changes).
Less serious side effects may include:
- mild nausea, vomiting, bloating, stomach cramps;
- diarrhea, constipation, bloating;
- dizziness, drowsiness, tired feeling;
- pain in your vaginal or rectal area;
- pain during intercourse;
- loss of interest in sex;
- breast pain, swelling, or tenderness;
- joint or muscle pain;
- increased night-time urination; or
- vaginal itching, burning, or discharge.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the Crinone (progesterone gel) Side Effects Center for a complete guide to possible side effects
What is the most important information I should know about progesterone vaginal?
Do not use progesterone vaginal without your doctor's consent if you are pregnant, unless you are using the medication as part of your fertility treatment. Tell your doctor if you become pregnant during treatment. If you are not being treated for infertility, use an effective form of birth control while you are using this medication.
Some forms of this medication may contain plant-based oils. Do not use progesterone vaginal without telling your doctor if you have any type of food allergy.
Using progesterone vaginal can increase your risk of blood clots, stroke, heart attack, or breast cancer.
You should not use this medication if you have: a history of stroke or blood clot, circulation problems, severe liver disease, a hormone-related cancer such as breast or uterine cancer, abnormal vaginal bleeding, or if you have recently had a tubal pregnancy or an incomplete abortion.
Progesterone vaginal is sometimes given for only 6 to 12 days at a time. When used as part of fertility treatment, progesterone vaginal may be given for up to 12 weeks into a pregnancy. Following your dosing schedule is very important for this medication to be effective. Try not to miss any doses.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Progesterone vaginal can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Additional Crinone Information
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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