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There have been more than 60 reports of acute or chronic human overdosage (up to 23 times the recommended total daily dose of 2400 mg) with CRIXIVAN. The most commonly reported symptoms were renal (e.g., nephrolithiasis/urolithiasis, flank pain, hematuria) and gastrointestinal (e.g., nausea, vomiting, diarrhea).

It is not known whether CRIXIVAN is dialyzable by peritoneal or hemodialysis.


CRIXIVAN is contraindicated in patients with clinically significant hypersensitivity to any of its components.

Inhibition of CYP3A4 by CRIXIVAN can result in elevated plasma concentrations of the following drugs, potentially causing serious or life-threatening reactions:

Table 7: Drug Interactions With Crixivan: Contraindicated Drugs

Drug Class Drugs Within Class That Are Contraindicated With CRIXIVAN
Alpha 1-adrenoreceptor antagonist alfuzosin
Antiarrhythmics amiodarone
Ergot derivatives dihydroergotamine, ergonovine, ergotamine, methylergonovine
GI motility agents cisapride
HMG-CoA Reductase Inhibitors lovastatin, simvastatin
Neuroleptics pimozide
PDE5 Inhibitors Revatio (sildenafil) [for treatment of pulmonary arterial hypertension]
Sedative/hypnotics oral midazolam, triazolam, alprazolam
* Registered trademark of Pfizer, Inc.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 4/4/2016


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