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There have been more than 60 reports of acute or chronic human overdosage (up to 23 times the recommended total daily dose of 2400 mg) with CRIXIVAN. The most commonly reported symptoms were renal (e.g., nephrolithiasis/urolithiasis, flank pain, hematuria) and gastrointestinal (e.g., nausea, vomiting, diarrhea).
CRIXIVAN is contraindicated in patients with clinically significant hypersensitivity to any of its components.
Inhibition of CYP3A4 by CRIXIVAN can result in elevated plasma concentrations of the following drugs, potentially causing serious or life-threatening reactions:
Table 7: Drug Interactions
With Crixivan: Contraindicated Drugs
|Drug Class||Drugs Within Class That Are Contraindicated With CRIXIVAN|
|Alpha 1-adrenoreceptor antagonist||alfuzosin|
|Ergot derivatives||dihydroergotamine, ergonovine, ergotamine, methylergonovine|
|GI motility agents||cisapride|
|HMG-CoA Reductase Inhibitors||lovastatin, simvastatin|
|PDE5 Inhibitors||Revatio (sildenafil) [for treatment of pulmonary arterial hypertension]|
|Sedative/hypnotics||oral midazolam, triazolam, alprazolam|
|* Registered trademark of Pfizer, Inc.|
Last reviewed on RxList: 8/7/2014
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