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home > drugs a-z list > crixivan (indinavir sulfate) drug center > crixivan (indinavir sulfate) drug - overdosage and contraindications
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Crixivan
HIV and AIDS: Antiretroviral Drugs, Treatments and Medications »
Entry Inhibitors (including Fusion Inhibitors) and CCR5 Co-receptor Antagonist
Entry Inhibitors
Entry inhibitors block HIV entry into CD4+ cells.
Fusion inhibitors
The only drug in this class is T-20, which is administered as a twice daily subcutaneous injection. The most common side effect is redness and pain at the site of injection. Rarely, infection can occur at the injection site. There also are reports of generalized allergic reactions.
CCR5 antagonist
Although there were some early concerns of liver inflammation for drugs in this class, MVC appeared to be well tolerated in clinical trials without any specific toxicities attributable to the drug. However, it is a new drug in a new class and the first to actually target the cell. For these reasons, longer follow-up from clinical trials and those followed in the clinic will be very important for assessing the overall safety of the...
Read the HIV and AIDS: Antiretroviral Drugs, Treatments and Medications article »
Crixivan
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OVERDOSE
There have been more than 60 reports of acute or chronic human overdosage (up to 23 times the recommended total daily dose of 2400 mg) with CRIXIVAN. The most commonly reported symptoms were renal (e.g., nephrolithiasis/urolithiasis, flank pain, hematuria) and gastrointestinal (e.g., nausea, vomiting, diarrhea).
It is not known whether CRIXIVAN is dialyzable by peritoneal or hemodialysis.
CONTRAINDICATIONS
CRIXIVAN is contraindicated in patients with clinically significant hypersensitivity to any of its components.
Inhibition of CYP3A4 by CRIXIVAN can result in elevated plasma concentrations of the following drugs, potentially causing serious or life-threatening reactions:
Table 7 : Drug Interactions
With Crixivan: Contraindicated Drugs
| Druq Class | Druqs Within Class That Are Contraindicated With CRIXIVAN |
| Alpha 1-adrenoreceptor antagonist | alfuzosin |
| Antiarrhythmics | amiodarone |
| Ergot derivatives | dihydroergotamine, ergonovine, ergotamine, methylergonovine |
| GI motility agents | cisapride |
| HMG-CoA Reductase Inhibitors | lovastatin, simvastatin |
| Neuroleptics | pimozide |
| PDE5 Inhibitors | Revatio1 (sildenafil) [for treatment of pulmonary arterial hypertension] |
| Sedative/hypnotics | oral midazolam, triazolam, alprazolam |
| 1Registered trademark of Pfizer, Inc. | |
Last reviewed on RxList: 3/2/2012
This monograph has been modified to include the generic and brand name in many instances.
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