Crohn's Disease (cont.)
Jay W. Marks, MD
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
In this Article
- Crohn's disease facts
- What is Crohn's disease?
- What causes Crohn's disease?
- How does Crohn's disease affect the intestines?
- How is Crohn's disease different from ulcerative colitis?
- What are the symptoms of Crohn's disease?
- What are the complications of Crohn's disease?
- How is Crohn's disease diagnosed?
- How is Crohn's disease treated?
- Crohn's Disease Medications
- Anti-inflammatory medications
- 5-ASA (mesalamine) oral medications
- 5-ASA rectal medications (Rowasa, Canasa)
- Corticosteroids
- Budesonide (Entocort EC)
- Antibiotics
- Immuno-modulator medications
- Azathioprine (Imuran) and 6-mercaptopurine (6-MP, Purinethol)
- Infliximab (Remicade)
- Adalimumab (Humira)
- Certolizumab pegol (Cimzia)
- Natalizumab (Tysabri)
- Methotrexate
- Surgery in Crohn's disease
- Are there any recommendations for diet and supplementation for Crohn's disease?
- Conclusions
- Pictures of Digestive Disease Myths - Slideshow
- Take the Quiz: Tummy Trouble Digestive Disorders
- Pictures of Diverticulitis (Diverticulosis) - Slideshow
- Find a local Gastroenterologist in your town
Conclusions
Crohn's disease is a chronic inflammatory disease involving predominantly the small intestine and colon. The symptoms and the activity of the disease can come and go. Even though many effective medications are available to control the activity of the disease, there is as yet no cure for Crohn's disease. Surgery can significantly improve the quality of life in selected individuals, but recurrence of the disease after surgery is common. The disease can have complications, both within and outside of the intestine. Newer treatments are actively being evaluated. A better understanding of the role of genetics and environmental factors in the cause of Crohn's disease may lead to improved treatments and prevention of the disease.
REFERENCES:
1. Caprilli, R and Frieri, G. The dyspeptic macrophage 30 years
later: An update in the pathogenesis of Crohns disease. Digestive
and Liver Disease (2009) 41, 166-168.
2. Noomen, CG et al. Update on Genetics in Inflammatory Disease.
Best Practice and Research Clinical Gastroenterology (2009)
23, 233-243.
3. Lichtenstein, GR et al. Management of Crohns Disease in
Adults. The American Journal of Gastroenterology (2009), 1-19.
4. Hanauer, SB. Medical Management of Crohns Disease: Treatment
Algorithms 2009. Digestive Diseases (2009) 27, 536-541.
5. Biologic Therapies for Crohns Disease: Update from the 2009
ACG Meeting. Gastroenterology and Hepatology (2010), Vol 6, Iss 1,
Supp 2.
6. Sandborn, WJ et al. Certolizumab Pegol for the Treatment of
Crohns Disease. The New England Journal of Medicine (2007) 357,
228-238.
7. Ghosh, S et al. Natalizumab for Active Crohns Disease. The
New England Journal of Medicine (2003) 348, 24-32.
8. Dignass, A et al. The Second European Evidence-Based
Consensus on the Diagnosis and Management of Crohns Disease:
Current Management. Journal of Crohns and Colitis (2010)
4, 28-62.
9. Assche, GV et al. The Second European Evidence-Based
Consensus on the Diagnosis and Management of Crohns Disease:
Special Situations. Journal of Crohns and Colitis (2010)
4, 63-101.
10. Assche, GV et al. The Second European Evidence-Based
Consensus on the Diagnosis and Management of Crohns Disease:
Definitions and Diagnosis. Journal of Crohns and Colitis
(2010) 4, 7-27.
11. Moscandrew, M, Mahadevan, U, and Kane, S. General Health
Maintenance in IBD. Inflammatory Bowel Disease (2009) 15, 1399-1409.
12. Juillerat, P et al. Extraintestinal Manifestations of Crohns
Disease. Digestion (2007) 76, 141-148.
13. Colombel, JF et al. Adalimumab for the Treatment of fistulas
in Patients with Crohns disease. Gut (2009).
14. DHaens, G et al. Early combined immunosuppression or
conventional management in patients with newly diagnosed Crohns
disease: an open randomized trial. Lancet (2008) 371, 660-667.
15. Kader, HA et al. Normal thiopurine methyltransferase levels
do not eliminate 6-mercaptopurine or azathioprine activity in
children with inflammatory bowel disease. Journal of Clinical
Gastroenterology (Jun 2000) 30(4), 409-13.
Previous contributing authors: Dennis Lee, MD and Lori Kam, MD
Last Editorial Review: 11/17/2010
Patient Comments
Viewers share their comments
- •
- Submit »
http://www.medicinenet.com/crohns_disease/article.htm
Women's Health
Find out what women really need.






