May 26, 2017
Recommended Topic Related To:


"A deeper dive into data from the Trial Evaluating Cardiovascular Outcomes With Sitagliptin (TECOS) with the type 2 diabetes drug sitagliptin (Januvia, Merck), confirming that the dipeptidyl peptidase-4 (DPP-4) is not associated with any "...



(daptomycin) for injection


CUBICIN contains daptomycin, a cyclic lipopeptide antibacterial agent derived from the fermentation of Streptomyces roseosporus. The chemical name is N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-Lthreonylglycyl- L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3- anthraniloyl-L-alanine ε1-lactone. The chemical structure is:

CUBICIN® (daptomycin) Structural Formula Illustration

The empirical formula is C72H101N17O26; the molecular weight is 1620.67. CUBICIN is supplied in a single-use vial as a sterile, preservative-free, pale yellow to light brown, lyophilized cake containing approximately 500 mg of daptomycin for intravenous (IV) use following reconstitution with 0.9% sodium chloride injection [see DOSAGE AND ADMINISTRATION]. The only inactive ingredient is sodium hydroxide, which is used for pH adjustment. Freshly reconstituted solutions of CUBICIN range in color from pale yellow to light brown.

What are the possible side effects of daptomycin (Cubicin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • new or worsening cough, fever, trouble breathing;
  • pain or burning when you urinate;
  • diarrhea that is watery or bloody;
  • white patches or sores in your mouth or throat;
  • vaginal itching or discharge;
  • urinating less than usual or not at all;
  • muscle pain or weakness with fever or flu symptoms and dark...

Read All Potential Side Effects and See Pictures of Cubicin »

What are the precautions when taking daptomycin injection (Cubicin)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease or kidney dialysis, muscle problems (e.g., myopathy).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal...

Read All Potential Precautions of Cubicin »

Last reviewed on RxList: 7/25/2016
This monograph has been modified to include the generic and brand name in many instances.

Cubicin - User Reviews

Cubicin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Cubicin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Women's Health

Find out what women really need.