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In the event of overdosage, supportive care is advised with maintenance of glomerular filtration. Daptomycin is cleared slowly from the body by hemodialysis (approximately 15% of the administered dose is removed over 4 hours) and by peritoneal dialysis (approximately 11% of the administered dose is removed over 48 hours). The use of high-flux dialysis membranes during 4 hours of hemodialysis may increase the percentage of dose removed compared with that removed by low-flux membranes.


CUBICIN is contraindicated in patients with known hypersensitivity to daptomycin.

Last reviewed on RxList: 12/9/2013
This monograph has been modified to include the generic and brand name in many instances.


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