Cutivate Cream

Drug Description
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CUTIVATE®
(fluticasone propionate) Cream, 0.05%

Topical Anti-inflammatory Corticosteroid

DRUG DESCRIPTION

Drug Substance

Proper Name: fluticasone propionate (BAN, INN, USAN)

Chemical Name: S-fluoromethyl 6α,9α-difluoro-llβ-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-l,4-diene-17β-carbothioate

Structural Formula:

CUTIVATE®  (Fluticasone Propionate) Structural Formula Illustration

Molecular Formula: C25H31F305S

Molecular Weight: 500.6

Description: Fluticasone propionate is a white to off-white powder.

Solubility: Fluticasone propionate is freely soluble in dimethyl sulfoxide and dimethylformamide, sparingly soluble in acetone, dichlo-romethane, ethyl acetate and chloroform, slightly soluble in methanol and 95% ethanol, and practically insoluble in water.

Melting Point: Fluticasone propionate decomposes without melting.Onset of decomposition occurs at about 225ûC.

Composition

Each gram of CUTIVATE (fluticasone propionate) Cream, 0.05% w/w contains fluticasone propionate 500 micrograms in a cream base. Non-medicinal ingredients: propylene glycol, mineral oil, cetostearyl alcohol, polyoxyl 20 cetostearyl ether, isopropyl myristate, dibasic sodium phosphate, citric acid, purified water and imidurea as a preservative.

Last updated on RxList: 10/22/2008

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