Cycloset (Bromocriptine Mesylate Tablets) Drug Information: Overdosage and Contraindications

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May 27, 2012

Cycloset

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OVERDOSE

With another formulation of bromocriptine mesylate, the most commonly reported signs and symptoms associated with acute overdose were nausea, vomiting, constipation, diaphoresis, dizziness, pallor, severe hypotension, malaise, confusion, lethargy, drowsiness, delusions, hallucinations, and repetitive yawning. The lethal dose has not been established.

Treatment of overdose consists of removal of the drug by emesis (if conscious), gastric lavage, activated charcoal, or saline catharsis. Careful supervision and recording of fluid intake and output is essential. Hypotension should be treated by placing the patient in the Trendelenburg position and administering intravenous fluids. If satisfactory relief of hypotension cannot be achieved by using the above measures to their fullest extent, vasopressors should be considered.

CONTRAINDICATIONS

CYCLOSET (bromocriptine mesylate tablets) is contraindicated in

Patients with known hypersensitivity to bromocriptine, ergot-related drugs, or any of the excipients in CYCLOSET (bromocriptine mesylate tablets) .
Patients with syncopal migraine. Bromocriptine increases the likelihood of a hypotensive episode among patients with syncopal migraine. Loss of consciousness during a migraine may reflect dopamine receptor hypersensitivity. CYCLOSET (bromocriptine mesylate tablets) is a dopamine receptor agonist, and may, therefore, potentiate the risk for syncope in these patients.
Women who are nursing their children. CYCLOSET (bromocriptine mesylate tablets) may inhibit lactation. There are postmarketing reports of stroke in this patient population although causality has not been proven [See Nursing Mothers].

Last reviewed on RxList: 5/11/2011
This monograph has been modified to include the generic and brand name in many instances.