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Cyklokapron

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Cyklokapron

Cyklokapron

INDICATIONS

CYKLOKAPRON Injection is indicated in patients with hemophilia for short-term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction.

DOSAGE AND ADMINISTRATION

Immediately before tooth extraction in patients with hemophilia, administer 10 mg per kg body weight of CYKLOKAPRON intravenously together with replacement therapy (see PRECAUTIONS). Following tooth extraction, intravenous therapy, at a dose of 10 mg per kg body weight three to four times daily, may be used for 2 to 8 days.

Note: For patients with moderate to severe impaired renal function, the following dosages are recommended:

Serum Creatinine (μmol/L) Tranexamic Acid I.V. Dosage
120 to 250 (1.36 to 2.83 mg/dL) 10 mg/kg BID
250 to 500 (2.83 to 5.66 mg/dL) 10 mg/kg daily
> 500 ( > 5.66 mg/dL) 10 mg/kg every 48 hours or 5 mg/kg every 24 hours

For intravenous infusion, CYKLOKAPRON Injection may be mixed with most solutions for infusion such as electrolyte solutions, carbohydrate solutions, amino acid solutions, and Dextran solutions. The mixture should be prepared the same day the solution is to be used. Heparin may be added to CYKLOKAPRON Injection. CYKLOKAPRON Injection should NOT be mixed with blood. The drug is a synthetic amino acid, and should NOT be mixed with solutions containing penicillin.

HOW SUPPLIED

CYKLOKAPRON Injection 100 mg/mL

NDC 0013-1114-10 10 x 10 mL ampules

Storage

Store at 25°C (77°F); excursions permitted to 15°- 30°C (59°- 86°F) [see USP Controlled Room Temperature].

Distributed by: Pharmacia & Upjohn Co., Division of Pfizer Inc, New York, NY10017. April 2013

Last reviewed on RxList: 6/3/2013
This monograph has been modified to include the generic and brand name in many instances.

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