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Cases of overdosage of CYKLOKAPRON (tranexamic acid) have been reported. Based on these reports, symptoms of overdosage may be gastrointestinal, e.g., nausea, vomiting, diarrhea; hypotensive, e.g., orthostatic symptoms; thromboembolic, e.g., arterial, venous, embolic; visual impairment; mental status changes; myoclonus, and rash.

CYKLOKAPRON (tranexamic acid) Injection is contraindicated:

1. In patients with acquired defective color vision, since this prohibits measuring one endpoint that should be followed as a measure of toxicity (see WARNINGS).
2. In patients with subarachnoid hemorrhage. Anecdotal experience indicates that cerebral edema and cerebral infarction may be caused by CYKLOKAPRON (tranexamic acid) in such patients.
3. In patients with active intravascular clotting.

Last reviewed on RxList: 2/17/2009
This monograph has been modified to include the generic and brand name in many instances.