Cylert (Pemoline) Drug Information: Overdosage and Contraindications

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May 27, 2012

Cylert

Narcolepsy »

What is narcolepsy?

Narcolepsy is a chronic disease of the central nervous system. Excessive daytime sleepiness (EDS) is the main symptom and is present in 100% of patients with narcolepsy. Other primary symptoms of narcolepsy include:

loss of muscle tone (cataplexy),
distorted perceptions (hypnagogic hallucinations), and
inability to move or talk (sleep paralysis).

Additional symptoms include disturbed nocturnal sleep and automatic behavior (patients carry out certain actions without conscious awareness). All of the symptoms of narcolepsy may be present in various combinations and degrees of severity.

Narcolepsy usually begins in teenagers or young adults and affects both sexes equally. The first symptom to appear is excessive daytime sleepiness, which may remain unrecognized for a long time in that it develops gradually over time. The other symptoms can follow excessive daytime sleepiness by months...

Read the Narcolepsy article »

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Cylert

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

OVERDOSE

Signs and symptoms of acute overdosage, resulting principally from overstimulation of the central nervous system and from excessive sympathomimetic effects, may include the following: vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, hypertension and mydriasis. Consult with a Certified Poison Control Center regarding treatment for up to date guidance and advice. Treatment consists of appropriate supportive measures. The patient must be protected against self-injury and against external stimuli that would aggravate overstimulation already present. Gastric contents may be evacuated by gastric lavage. Other measures to detoxify the gut include administration of activated charcoal and a cathartic. Chlorpromazine has been reported in the literature to be useful in decreasing CNS stimulation and sympathomimetic effects.

Efficacy of peritoneal dialysis or extracorporeal hemodialysis for CYLERT (pemoline) overdosage has not been established.

CONTRAINDICATIONS

CYLERT (pemoline) is contraindicated in patients with known hypersensitivity or idiosyncrasy to the drug. CYLERT (pemoline) should not be administered to patients with impaired hepatic function (see ADVERSE REACTIONS).

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.