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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Cylert Patient Information including How Should I Take

Who should not take pemoline (Cylert)?

Before taking this medication, tell your doctor if you have

  • liver disease,
  • kidney disease,
  • seizures or epilepsy,
  • Tourette's syndrome, or
  • a history of drug or alcohol abuse.

You may not be able to take pemoline or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Pemoline is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take pemoline without first talking to your doctor if you are pregnant.

It is also not known whether pemoline passes into breast milk. Do not take pemoline without first talking to your doctor if you are breast-feeding a baby.

The safety and effectiveness of pemoline for use by children younger than 6 years of age have not been established.

How should I take pemoline (Cylert)?

Take this medication exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain the instructions to you.

Take each dose with a full glass of water.

Pemoline is usually taken once a day in the morning. Follow your doctor's instructions.

In rare cases, pemoline has caused severe liver damage resulting in death or liver transplant. Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, itching, clay-colored stools, or dark urine. These symptoms may be early signs of liver damage. Before taking pemoline, you will be required to discuss with your doctor the risks and benefits of this medicine and to sign an informed consent stating that you understand these risks and benefits. Also, your doctor will need to monitor your liver function with blood tests before starting therapy with pemoline, and every two weeks thereafter.

Store pemoline at room temperature away from moisture and heat.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Women's Health

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