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Cyproheptadine

Last reviewed on RxList: 7/14/2017
Cyproheptadine Side Effects Center

Last reviewed on RxList 7/14/2017

Cyproheptadine (cyproheptadine hydrochloride) is an antihistamine used to treat sneezing, itching, watery eyes, runny nose, and other symptoms of allergies. Cyproheptadine is available in generic form. Common side effects of Cyproheptadine include:

  • drowsiness,
  • tired feeling,
  • sleep problems (insomnia),
  • dizziness,
  • spinning sensation,
  • blurred vision,
  • loss of coordination,
  • upset stomach,
  • nausea,
  • diarrhea,
  • constipation,
  • appetite changes,
  • weight gain,
  • restlessness or excitability (especially in children),
  • numbness or tingly feeling,
  • increased sweating or urination,
  • thickening of mucus in the nose/throat, or
  • dry mouth/throat/nose.

Tell your doctor if you have serious side effects of Cyproheptadine including:

  • mental/mood changes (such as restlessness, confusion, hallucinations),
  • shaking (tremor),
  • difficulty urinating, or
  • fast/irregular heartbeat.

Adult dosing for cyproheptadine ranges from 4 mg to 20 mg per day. Pediatric dosing is usually calculated based on body weight. Cyproheptadine may adversely interact with some medications including anticholinergic drugs, antispasmodic drugs, drugs for Parkinson's disease, MAO inhibitors, SSRI antidepressants, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, narcotic pain relievers, psychiatric medicines, or any medication that may cause drowsiness, including cough-and-cold products. This medication should be used only when prescribed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication passes into breast milk. Due to the potential risk to the nursing infant, breastfeeding while using this drug is not recommended. Consult your doctor before breastfeeding.

Our Cyproheptadine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Cyproheptadine Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking cyproheptadine and call your doctor at once if you have a serious side effect such as:

  • confusion, hallucinations, unusual thoughts or behavior;
  • seizure (convulsions);
  • ringing in your ears;
  • feeling like you might pass out;
  • fast or pounding heartbeats;
  • easy bruising or bleeding;
  • urinating less than usual or not at all; or
  • pale or yellowed skin, dark colored urine, fever, or unusual weakness.

Less serious side effects may include:

  • mild drowsiness, dizziness, or spinning sensation;
  • feeling restlessness or excited (especially in children);
  • sleep problems (insomnia), tired feeling;
  • numbness or tingly feeling;
  • increased sweating or urination;
  • blurred vision;
  • appetite changes;
  • dry mouth or nose, upset stomach; or
  • nausea, diarrhea, constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Cyproheptadine (Cyproheptadine Hydrochloride)

Cyproheptadine Professional Information

SIDE EFFECTS

Adverse reactions which have been reported with the use of antihistamines are as follows:

Central Nervous System

Sedation and sleepiness (often transient), dizziness, disturbed coordination, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, paresthesias, neuritis, convulsions, euphoria, hallucinations, hysteria, faintness.

Integumentary

Allergic manifestation of rash and edema, excessive perspiration, urticaria, photosensitivity.

Special Senses

Acute labyrinthitis, blurred vision, diplopia, vertigo, tinnitus.

Cardiovascular

Hypotension, palpitation, tachycardia, extrasystoles, anaphylactic shock.

Hematologic

Hemolytic anemia, leukopenia, agranulocytosis, thrombocytopenia.

Digestive System

Cholestasis, hepatic failure, hepatitis, hepatic function abnormality, dryness of mouth, epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation, jaundice.

Genitourinary

Urinary frequency, difficult urination, urinary retention, early menses.

Respiratory

Dryness of nose and throat, thickening of bronchial secretions, tightness of chest and wheezing, nasal stuffiness.

Miscellaneous

Fatigue, chills, headache, increased appetite/weight gain.

Read the entire FDA prescribing information for Cyproheptadine (Cyproheptadine Hydrochloride)

Related Resources for Cyproheptadine

Read the Cyproheptadine User Reviews »

© Cyproheptadine Patient Information is supplied by Cerner Multum, Inc. and Cyproheptadine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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