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There is no antidote for cytarabine overdosage. Doses of 4.5 g/m2 by intravenous infusion over 1 hour every 12 hours for 12 doses has caused an unacceptable increase in irreversible CNS toxicity and death.
Single doses as high as 3 g/m2 have been administered by rapid intravenous infusion without apparent toxicity.
Cytarabine is contraindicated in those patients who are hypersensitive to the drug.
Last reviewed on RxList: 11/3/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Cytarabine Information
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