"The U.S. Food and Drug Administration today expanded the approved uses of Abraxane (paclitaxel protein-bound particles for injectable suspension, albumin-bound) to treat patients with late-stage (metastatic) pancreatic cancer.
(cyclophosphamide) for Injection, USP
Cytoxan (cyclophosphamide) is a synthetic antineoplastic drug chemically related to the nitrogen mustards. The chemical name for cyclophosphamide is 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate, and has the following structural formula:
Cyclophosphamide has a molecular formula of C7H15Cl2N2O2P•H2O and a molecular weight of 279.1. Cyclophosphamide is soluble in water, saline, or ethanol.
Cyclophosphamide for Injection, USP is a sterile white cake available as 500 mg, 1 g, and 2 g strength vials.
- 500 mg vial contains 534.5 mg cyclophosphamide monohydrate equivalent to 500 mg cyclophosphamide and 375 mg mannitol
- 1 g vial contains 1069.0 mg cyclophosphamide monohydrate equivalent to 1 g cyclophosphamide and 750 mg mannitol
- 2 g vial contains 2138.0 mg cyclophosphamide monohydrate equivalent to 2 g cyclophosphamide and 1500 mg mannitol
Cyclophosphamide Tablets, USP are for oral use and contain 25 mg or 50 mg cyclophosphamide (anhydrous). Inactive ingredients in Cyclophosphamide Tablets are: acacia, FD&C Blue No. 1, D&C Yellow No. 10 Aluminum Lake, lactose, magnesium stearate, starch, stearic acid and talc.
What are the possible side effects of cyclophosphamide (Cytoxan, Neosar)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- blood in your urine or stools, pain or burning when you urinate;
- pale skin, feeling light-headed, rapid heart rate, trouble concentrating;
- sudden chest pain or discomfort, wheezing, dry cough or hack, feeling short of breath on exertion;
- fever, chills, body aches, flu symptoms, sores in your mouth and...
What are the precautions when taking cyclophosphamide (Cytoxan)?
Before taking cyclophosphamide, tell your doctor or pharmacist if you are allergic to it; or to other chemotherapy drugs (e.g., busulfan, chlorambucil); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: decreased bone marrow function (e.g., anemia, leukopenia, thrombocytopenia).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, surgery to remove your adrenal glands.
Do not have immunizations/vaccinations without...
Last reviewed on RxList: 6/13/2013
This monograph has been modified to include the generic and brand name in many instances.
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