Cytoxan (Cyclophosphamide) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 3, 2012

Cytoxan

Ovarian Cancer »

Ovarian cancer facts*

*Ovarian cancer facts medically edited by Melissa Conrad Stöppler, MD

Most ovarian growths in women under age 30 are benign, fluid-filled cysts.

There are several types of ovarian cancer.

The exact causes of ovarian cancer are unknown.

Risk factors that increase the chance of developing ovarian cancer include a family history of cancer, being over 55 years of age, and never being pregnant.

The ovarian cancer symptoms and signs can be vague but may include abdominal swelling, pressure, or pain, frequent urination or urinary urgency, back pain, leg pain, unusual vaginal bleeding, and feeling full quickly.

There are no routine screening tests for ovarian cancer.

A physical examination (including pelvic exam), ultrasound, X-rays, ...

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CYTOXAN®
(cyclophosphamide) for Injection, USP

DRUG DESCRIPTION

CYTOXAN® (cyclophosphamide for injection, USP) is a sterile white powder containing cyclophosphamide monohydrate. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Cyclophosphamide is a white crystalline powder with the molecular formula C₇H₁₅C_l2N₂O₂P•H₂O and a molecular weight of 279.1. The chemical name for cyclophosphamide is 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate. Cyclophosphamide is soluble in water, saline, or ethanol and has the following structural formula:

CYTOXAN® (cyclophosphamide) structural formula illustration

What are the possible side effects of cyclophosphamide (Cytoxan, Cytoxan Lyophilized, Neosar)?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
blood in the urine;
black or tarry stools;
painful or difficult urination;
signs of infection such as fever; chills, or sore throat;
jaundice (yellowing of the skin or...

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What are the precautions when taking cyclophosphamide (Cytoxan)?

Before taking cyclophosphamide, tell your doctor or pharmacist if you are allergic to it; or to other chemotherapy drugs (e.g., busulfan, chlorambucil); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: decreased bone marrow function (e.g., anemia, leukopenia, thrombocytopenia).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, surgery to remove your adrenal glands.

Do not have immunizations/vaccinations without...

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Last reviewed on RxList: 10/25/2010
This monograph has been modified to include the generic and brand name in many instances.