Recommended Topic Related To:

Cytoxan

"Sept. 26, 2014 -- Spotting cancer early is key, but trying to do that -- often when there are no symptoms -- has been challenging.

Still, more and more evidence suggests that all cancers have a sign"...

Cytoxan

Overdosage
Contraindications

OVERDOSE

No specific antidote for cyclophosphamide is known.

Overdosage should be managed with supportive measures, including appropriate treatment for any concurrent infection, myelosuppression, or cardiac toxicity should it occur.

Serious consequences of overdosage include manifestations of dose dependent toxicities such as myelosuppression, urotoxicity, cardiotoxicity (including cardiac failure), veno-occlusive hepatic disease, and stomatitis [see WARNINGS AND PRECAUTIONS].

Patients who received an overdose should be closely monitored for the development of toxicities, and hematologic toxicity in particular.

Cytoxan (cyclophosphamide) and its metabolites are dialyzable. Therefore, rapid hemodialysis is indicated when treating any suicidal or accidental overdose or intoxication.

Cystitis prophylaxis with mesna may be helpful in preventing or limiting urotoxic effects with cyclophosphamide overdose.

CONTRAINDICATIONS

  • Hypersensitivity

Cyclophosphamide is contraindicated in patients who have a history of severe hypersensitivity reactions to it, any of its metabolites, or to other components of the product. Anaphylactic reactions including death have been reported with cyclophosphamide. Possible cross-sensitivity with other alkylating agents can occur.

  • Urinary Outflow Obstruction

Cyclophosphamide is contraindicated in patients with urinary outflow obstruction [see WARNINGS AND PRECAUTIONS].

Last reviewed on RxList: 6/13/2013
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
A A A

Cytoxan - User Reviews

Cytoxan User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Cytoxan sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Cancer

Get the latest treatment options.