"The U.S. Food and Drug Administration today expanded the approved use of Opdivo (nivolumab) to treat patients with advanced (metastatic) squamous non-small cell lung cancer (NSCLC) with progression on or after platinum-based chemotherapy.
Cytoxan Patient Information Including Side Effects
Brand Names: Cytoxan, Neosar
Generic Name: cyclophosphamide (oral/injection) (Pronunciation: sye kloe FOSS fa mide)
- What is cyclophosphamide (Cytoxan)?
- What are the possible side effects of cyclophosphamide (Cytoxan)?
- What is the most important information I should know about cyclophosphamide (Cytoxan)?
- What should I discuss with my healthcare provider before taking cyclophosphamide (Cytoxan)?
- How is cyclophosphamide given (Cytoxan)?
- What happens if I miss a dose (Cytoxan)?
- What happens if I overdose (Cytoxan)?
- What should I avoid while taking cyclophosphamide (Cytoxan)?
- What other drugs will affect cyclophosphamide (Cytoxan)?
- Where can I get more information?
What is cyclophosphamide (Cytoxan)?
Cyclophosphamide is a cancer medication that interferes with the growth and spread of cancer cells in the body.
Cyclophosphamide is used to treat several types of cancer. Cyclophosphamide is also used to treat certain cases of nephrotic syndrome (kidney disease) in children.
Cyclophosphamide may also be used for purposes not listed in this medication guide.
Cyclophosphamide 25 mg-ROX
round, blue, imprinted with 54 639
Cyclophosphamide 50 mg-ROX
round, blue, imprinted with 54 980
Cytoxan 25 mg
round, white/blue specks, imprinted with 25, MJ 504
Cytoxan 50 mg
round, white/blue specks, imprinted with 50, MJ 503
What are the possible side effects of cyclophosphamide (Cytoxan)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- blood in your urine or stools, pain or burning when you urinate;
- pale skin, feeling light-headed, rapid heart rate, trouble concentrating;
- sudden chest pain or discomfort, wheezing, dry cough or hack, feeling short of breath on exertion;
- fever, chills, body aches, flu symptoms, sores in your mouth and throat;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- extreme thirst with headache, vomiting, and weakness;
- jaundice (yellowing of the skin or eyes); or
- severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Other common side effects may include:
- nausea, loss of appetite, stomach pain or upset, diarrhea;
- temporary hair loss;
- a wound that will not heal;
- missed menstrual periods;
- changes in skin color; or
- changes in nails.
In some cases, secondary cancers have been reported to occur during and following treatment with cyclophosphamide. Talk to your doctor about the risks and benefits of this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the Cytoxan (cyclophosphamide) Side Effects Center for a complete guide to possible side effects
What is the most important information I should know about cyclophosphamide (Cytoxan)?
You should not use cyclophosphamide if you are allergic to it, or if you have severe bone marrow suppression.
Before you receive cyclophosphamide, tell your doctor if you have an active or recent infection, a weak immune system, heart disease, liver or kidney disease, or if you have ever been treated with radiation. Tell your doctor about all other cancer medications and treatments you are receiving.
Cyclophosphamide can lower blood cells that help your body fight infections and help your blood to clot. Your blood may need to be tested often. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding injury. Tell your doctor at once if you develop signs of infection.
Drink plenty of liquids while you are using cyclophosphamide, to prevent harmful effects on your bladder.
Additional Cytoxan Information
- Cytoxan Drug Interactions Center: cyclophosphamide oral
- Cytoxan Side Effects Center
- Cytoxan Overview including Precautions
- Cytoxan FDA Approved Prescribing Information including Dosage
Cytoxan - User Reviews
Cytoxan User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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