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Dalmane

Last reviewed on RxList: 4/19/2017
Dalmane Side Effects Center

Last reviewed on RxList 12/28/2016

Dalmane (flurazepam) is a benzodiazepine used to treat insomnia symptoms, such as trouble falling or staying asleep. Dalmane is available in generic form. Common side effects of Dalmane include:

  • dizziness,
  • weakness,
  • loss of coordination,
  • blurred vision,
  • headache,
  • depression,
  • stomach pain,
  • heartburn,
  • upset stomach,
  • nausea,
  • vomiting,
  • diarrhea,
  • constipation,
  • nervousness,
  • excited feeling,
  • irritability,
  • increased sweating,
  • flushing (warmth, redness, or tingly feeling),
  • itching or rash,
  • dry mouth, or
  • unpleasant taste in your mouth.

Tell your doctor if you have daytime drowsiness (or during hours when you are not normally sleeping) when using Dalmane. Some people using Dalmane have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking Dalmane and talk to your doctor. Tell your doctor if you have serious side effects of Dalmane including:

  • memory loss, or
  • mental/mood/behavior changes (such as new or worsening depression, abnormal thoughts, thoughts of suicide, hallucinations, confusion, agitation, aggressive behavior, or anxiety).

Dosage of Dalmane should be individualized. The usual adult dosage is 30 mg before bedtime. In some patients, 15 mg may suffice. Dalmane may interact with fluvoxamine, itraconazole, ketoconazole, or nefazodone. Tell your doctor all medications you are taking. Dalmane must not be used during pregnancy. Other medications in this class have caused birth defects when used in the first three months of pregnancy. Other medications in this class have also caused unusual drowsiness, feeding problems, and liver problems in newborns when used at or near the time of delivery, or withdrawal symptoms in newborns when used for a long time during pregnancy. If you are a woman of childbearing age, use an effective form of birth control while taking Dalmane. If you plan to become pregnant, stop taking this drug before doing so. If you become pregnant or think you may be pregnant, inform your doctor immediately. Based on information from related drugs, Dalmane may pass into breast milk and may have undesirable effects on a nursing infant. Breastfeeding while using this drug is not recommended. Dalmane may be habit-forming and should be used only by the person it was prescribed for.

Our Dalmane (flurazepam) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dalmane Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • feeling like you might pass out;
  • staggering walk, loss of balance or coordination;
  • agitation, confusion, slurred speech, hallucinations, feelings of extreme happiness or sadness;
  • chest pain, fast or pounding heartbeats, feeling short of breath;
  • fever, chills, body aches, flu symptoms;
  • problems with urination;
  • vision problems, burning in your eyes; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • dizziness, weakness, daytime drowsiness (or during hours when you are not normally sleeping);
  • headache, blurred vision, depressed mood;
  • stomach pain, heartburn, upset stomach, nausea, vomiting, diarrhea, constipation;
  • feeling nervous, excited, or irritable;
  • increased sweating;
  • flushing (warmth, redness, or tingly feeling);
  • mild itching or rash; or
  • dry mouth, unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Dalmane (Flurazepam)

Dalmane Professional Information

SIDE EFFECTS

Dizziness, drowsiness, light-headedness, staggering, ataxia and falling have occurred, particularly in elderly or debilitated persons. Severe sedation, lethargy, disorientation and coma, probably indicative of drug intolerance or overdosage, have been reported.

Also reported were headache, heartburn, upset stomach, nausea, vomiting, diarrhea, constipation, gastrointestinal pain, nervousness, talkativeness, apprehension, irritability, weakness, palpitations, chest pains, body and joint pains and genitourinary complaints. There have also been rare occurrences of leukopenia, granulocytopenia, sweating, flushes, difficulty in focusing, blurred vision, burning eyes, faintness, hypotension, shortness of breath, pruritus, skin rash, dry mouth, bitter taste, excessive salivation, anorexia, euphoria, depression, slurred speech, confusion, restlessness, hallucinations, and elevated SGOT, SGPT, total and direct bilirubins, and alkaline phosphatase. Paradoxical reactions, eg, excitement, stimulation and hyperactivity, have also been reported in rare instances.

DRUG ABUSE AND DEPENDENCE

Abuse and addiction are separate and distinct from physical dependence and tolerance. Abuse is characterized by misuse of the drug for non-medical purposes, often in combination with other psychoactive substances. Physical dependence is a state of adaptation that is manifested by a specific withdrawal syndrome that can be produced by abrupt cessation, rapid dose reduction, decreasing blood level of the drug and/or administration of an antagonist. Tolerance is a state of adaptation in which exposure to a drug induces changes that result in a diminution of one or more of the drug's effects over time. Tolerance may occur to both the desired and undesired effects of the drug and may develop at different rates for different effects.

Addiction is a primary, chronic, neurobiological disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. It is characterized by behaviors that include one or more of the following: impaired control over drug use, compulsive use, continued use despite harm, and craving. Drug addiction is a treatable disease, utilizing a multidisciplinary approach, but relapse is common.

Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of benzodiazepines. The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms (eg, dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving flurazepam or other psychotropic agents because of the predisposition of such patients to habituation and dependence.

Read the entire FDA prescribing information for Dalmane (Flurazepam)

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