Danshen

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Are there any interactions with medications?



Digoxin (Lanoxin)
Interaction Rating: Major Do not take this combination.

Digoxin (Lanoxin) helps the heart beat more strongly. Danshen also seems to affect the heart. Taking danshen along with digoxin can increase the effects of digoxin and increase the risk of side effects. Do not take danshen if you are taking digoxin (Lanoxin) without talking to your healthcare professional.



Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating: Major Do not take this combination.

Danshen might slow blood clotting. Taking danshen along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



Warfarin (Coumadin)
Interaction Rating: Major Do not take this combination.

Warfarin (Coumadin) is used to slow blood clotting. Danshen might increase how long warfarin (Coumadin) is in the body, and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.



Medications changed by the intestine (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the body. Danshen use might increase how quickly the body breaks down some medications. Taking danshen along with some medications that are broken down by the body can decrease the effectiveness of some medications. Before taking danshen talk to your healthcare provider if you are taking any medications that are changed by the body.

Some medications changed by the intestine include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and others.



Midazolam (Versed, others)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Midazolam (Versed) is changed and broken down by the body. Danshen might increase how quickly this medication is broken down by the body. Do not take danshen if you are taking midazolam (Versed).

Dosing considerations for Danshen.

The appropriate dose of danshen depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for danshen. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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