Dantrium IV (Dantrolene Sodium for Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Dantrium

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Dantrium IV

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Dantrium® Intravenous
(dantrolene sodium) Injection

DRUG DESCRIPTION

Dantrium Intravenous is a sterile, non-pyrogenic, lyophilized formulation of dantrolene sodium for injection. Dantrium Intravenous is supplied in 70 mL vials containing 20 mg dantrolene sodium, 3000 mg mannitol, and sufficient sodium hydroxide to yield a pH of approximately 9.5 when reconstituted with 60 mL sterile water for injection USP (without a bacteriostatic agent).

Dantrium is classified as a direct-acting skeletal muscle relaxant. Chemically, Dantrium is hydrated 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione sodium salt. The structural formula for the hydrated salt is:

Dantrium
(dantrolene sodium) Structural Formula Illustration

The hydrated salt contains approximately 15% water (3-1/2 moles) and has a molecular weight of 399. The anhydrous salt (dantrolene) has a molecular weight of 336.

Last reviewed on RxList: 12/22/2008
This monograph has been modified to include the generic and brand name in many instances.