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Dapsone

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Dapsone

Overdosage
Contraindications

OVERDOSE

Nausea, vomiting, hyperexcitability can appear a few minutes up to 24 hours after ingestion of an overdosage. Methemoglobin induced depression, convulsions or severe cyanosis requires prompt treatment. In normal and methemoglobin reductase deficient patients, methylene blue, 1-2 mg/kg of body weight, given slowly intravenously, is the treatment of choice. The effect is complete in 30 minutes, but may have to be repeated if methemoglobin reaccumulates. For non-emergencies, if treatment is needed, methylene blue may be given orally in doses of 3-5 mg/kg every 4-6 hours. Methylene blue reduction depends on G6PD and should not be given to fully expressed G6PD deficient patients.

CONTRAINDICATIONS

Hypersensitivity to Dapsone and/or its derivatives.

Last reviewed on RxList: 3/19/2014
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
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Dapsone - User Reviews

Dapsone User Reviews

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