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Dapsone

Last reviewed on RxList: 1/9/2017
Dapsone Side Effects Center

Last reviewed on RxList 10/12/2016

Dapsone is an antibacterial medication used in the treatment of dermatitis herpetiformis (a skin condition) and leprosy (Hansen's disease). Common side effects of dapsone include:

  • nausea,
  • vomiting,
  • loss of appetite,
  • dizziness,
  • blurred vision,
  • ringing in the ears,
  • headache,
  • insomnia, or
  • increased sensitivity of the skin to sunlight.

Tell your doctor if you have unlikely but serious side effects of dapsone including:

  • unusually fast heartbeat,
  • unusually fast breathing,
  • bluish lips or skin,
  • chest pain,
  • mental/mood changes,
  • muscle weakness, or
  • difficulty urinating.

The dosage of Dapsone is individually adjusted starting in adults with 50 mg daily and correspondingly smaller doses in children. If full control is not achieved within the range of 50-300 mg daily, higher doses may be tried. Dosage should be reduced to a minimum maintenance level as soon as possible. Other drugs can interact with Dapsone, especially those that may also affect the blood. Tell your doctor all prescription or over-the-counter medicines and supplements you use. During pregnancy, Dapsone should be used only when prescribed. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Our Dapsone Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dapsone Consumer Information

In rare cases, dapsone has been associated with serious, and sometimes fatal blood and/or liver problems. Contact your doctor immediately if you experience a sore throat, fever, pale skin, bruising or pinpoint red spots on the skin, or yellowing of the skin or eyes. These may be symptoms of blood or liver problems.

Contact your doctor immediately if you develop a rash while taking dapsone. In rare cases, dapsone has been associated with serious, and sometimes fatal, skin reactions.

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • bluish skin color;
  • muscle weakness;
  • numbness or tingling;
  • abdominal pain;
  • difficulty breathing;
  • dark colored urine or pale colored stools; or
  • unusual tiredness.

Other, less serious side effects may be more likely to occur. Notify your doctor if you experience

  • nausea or vomiting;
  • blurred vision;
  • ringing in the ears;
  • headache;
  • insomnia; or
  • increased sensitivity of the skin to sunlight.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Dapsone (Dapsone)

Dapsone Professional Information

SIDE EFFECTS

In addition to the warnings listed above, the following syndromes and serious reactions have been reported in patients on Dapsone.

Hematologic Effects

Dose-related hemolysis is the most common adverse effect and is seen in patients with or without G6PD deficiency. Almost all patients demonstrate the inter-related changes of a loss of 1-2g of hemoglobin, an increase in the reticulocytes (2-12%), a shortened red cell life span and a rise in methemoglobin. G6PD deficient patients have greater responses.

Nervous System Effects

Peripheral neuropathy is a definite but unusual complication of Dapsone therapy in non-leprosy patients. Motor loss is predominant. If muscle weakness appears, Dapsone should be withdrawn. Recovery on withdrawal is usually substantially complete. The mechanism of recovery is reported by axonal regeneration. Some recovered patients have tolerated retreatment at reduced dosage. In leprosy this complication may be difficult to distinguish from a leprosy reactional state.

Body As A Whole: In addition to the warnings and adverse effects reported above, additional adverse reactions include: nausea, vomiting, abdominal pains, pancreatitis, vertigo, blurred vision, tinnitus, insomnia, fever, headache, psychosis, phototoxicity, pulmonary eosinophilia, tachycardia, albuminuria, the nephrotic syndrome, hypoalbuminemia without proteinuria, renal papillary necrosis, male infertility, drug-induced Lupus erythematosus and an infectious mononucleosis-like syndrome. In general, with the exception of the complications of severe anoxia from overdosage (retinal and optic nerve damage, etc.) these adverse reactions have regressed off drug.

Read the entire FDA prescribing information for Dapsone (Dapsone)

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© Dapsone Patient Information is supplied by Cerner Multum, Inc. and Dapsone Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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