April 30, 2017
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Daraprim Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking pyrimethamine (Daraprim)?

Before taking pyrimethamine, tell your doctor if you have

  • had an allergic reaction to previous treatment with pyrimethamine,
  • megaloblastic anemia due to folate deficiency,
  • seizures or epilepsy,
  • kidney disease, or
  • liver disease.

You may not be able to take pyrimethamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Pyrimethamine is in the FDA pregnancy category C. This means that it is not known whether pyrimethamine will be harmful to an unborn baby. Do not take pyrimethamine without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Pyrimethamine passes into breast milk and may be harmful to a nursing infant. Do not take pyrimethamine without first talking to your doctor if you are breast-feeding a baby.

How should I take pyrimethamine (Daraprim)?

Take pyrimethamine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Take pyrimethamine with food to lessen stomach upset.

Store pyrimethamine at room temperature away from moisture and heat.

Side Effects Centers

Daraprim - User Reviews

Daraprim User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Daraprim sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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