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Daraprim Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Daraprim (pyrimethamine) is used to treat and prevent malaria, and is also used in the treatment of toxoplasmosis. It is an antiparasitic drug. Common side effects include nausea, vomiting, and loss of appetite.
The adult starting dose of Daraprim to treat toxoplasmosis is 50 to 75 mg daily, taken with 1 to 4 g daily of a sulfonamide of the sulfapyrimidine type. Pediatric dose to treat toxoplasmosis is determined by the child's weight. The adult dosage for acute malaria is 50 mg for 2 days; children 4 through 10 years old may be given 25 mg daily for 2 days. Daraprim may interact with auranofin, aurothioglucose, or gold sodium thiomalate. Tell your doctor all medications you use. During pregnancy, Daraprim should be used only when prescribed. Folic acid is very important during pregnancy. Your doctor will prescribe folic/folinic acid to prevent low folate levels. This medication passes into breast milk. Consult your doctor before breast-feeding.
Our Daraprim (pyrimethamine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Daraprim in Detail - Patient Information: Side Effects
Stop taking pyrimethamine and seek emergency medical attention if you experience an allergic reaction (swelling of the lips, tongue, or face; difficulty breathing; closing of the throat; or hives) during treatment with pyrimethamine.
Stop taking pyrimethamine and seek medical attention at the first sign of a skin rash, sore throat, paleness of the skin, unusual bruising under the skin, or swelling of the tongue. These may be early symptoms of serious side effects of pyrimethamine.
Other, less serious side effects may be more likely to occur. Continue to take pyrimethamine and talk to your doctor if you experience
- nausea, vomiting, or loss of appetite;
- lightheadedness; or
- dryness of the mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Daraprim (Pyrimethamine) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Daraprim Overview - Patient Information: Side Effects
Nausea, vomiting, and loss of appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Some people using this medication may develop serious side effects including blood problems, especially at higher doses. This risk can be reduced with the use of folic/folinic acid and regular blood tests. Tell your doctor immediately if any of these symptoms occur: easy bruising/bleeding, signs of serious infection (such as high fever, severe chills, persistent sore throat), signs of low red blood cell count (such as severe tiredness, pale lips/nails/skin, fast heartbeat/breathing with usual activities), swollen/painful tongue.
Seek immediate medical attention if any of these rare but very serious side effects occur: bloody/pink urine, chest pain, slow/fast/irregular heartbeat.
A very serious allergic reaction to this drug is rare. However, stop this medication immediately and seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Daraprim (Pyrimethamine)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Daraprim FDA Prescribing Information: Side Effects
Hypersensitivity reactions, occasionally severe (such as Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, and anaphylaxis), and hyperphenylalaninemia, can occur particularly when pyrimethamine is administered concomitantly with a sulfonamide.
Consult the complete prescribing information for the relevant sulfonamide for sulfonamide-associated adverse events. With doses of pyrimethamine used for the treatment of toxoplasmosis, anorexia and vomiting may occur. Vomiting may be minimized by giving the medication with meals; it usually disappears promptly upon reduction of dosage. Doses used in toxoplasmosis may produce megaloblastic anemia, leukopenia, thrombocytopenia, pancytopenia, atrophic glossitis, hematuria, and disorders of cardiac rhythm. Hematologic effects, however, may also occur at low doses in certain individuals (see PRECAUTIONS: General).
Pulmonary eosinophilia has been reported rarely.
Read the entire FDA prescribing information for Daraprim (Pyrimethamine) »
Additional Daraprim Information
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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