Darvon Compound (Propoxyphene, Aspirin, and Caffeine) Drug Information: Side Effects and Drug Interactions

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May 26, 2012

Darvon Compound

Restless Leg Syndrome »

What is restless leg syndrome (RLS)?

Restless leg syndrome (RLS, restless legs syndrome) is a common cause of painful legs. The leg pain of restless leg syndrome typically eases with motion of the legs and becomes more noticeable at rest. Restless leg syndrome also features worsening of symptoms and leg pain during the early evening or later at night.

Restless leg syndrome is often abbreviated RLS; it has also been termed shaking leg syndrome. Nighttime involuntary jerking of the legs during sleep are also known as periodic leg/limb movement disorder.

What causes restless leg syndrome?

The cause of restless leg syndrome is unknown in most people. However, restless leg syndrome has been associated with

pregnancy,
obesity,
smoking,
iron deficiency and anemia,
nerve disease,
polyneuropathy (which can be associated with hypothyroidism, heavy ...

Read the Restless Leg Syndrome article »

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

SIDE EFFECTS

In a survey conducted in hospitalized patients less than 1% of patients taking propoxyphene hydrochloride at recommended doses experienced side effects. The most frequently reported were dizziness, sedation, nausea and vomiting. Some of these adverse reactions may be alleviated if the patient lies down.

Other adverse reactions include constipation, abdominal pain, skin rashes, lightheadedness, headache, weakness, euphoria, dysphoria hallucinations, and minor visual disturbances.

Propoxyphene therapy has been associated with abnormal liver function tests and more rarely with instances of reversible jaundice (including cholestatic jaundice).

Renal papillary necrosis may result from chronic aspirin use, particularly when the dosage is greater than recommended and when combined with acetaminophen.

Subacute painful myopathy has occurred following chronic propoxyphene overdosage.

DRUG INTERACTIONS

The CNS-depressant effect of propoxyphene is additive with that of other CNS depressants, including alcohol.

Salicylates may enhance the effect of anticoagulants and inhibit the uric-casework effect of uricosuric agents.

As is the case with many medicinal agents propoxyphene may slow the metabolism of a concomitantly administered drug. Should this occur the higher serum concentrations of that drug may result in increased pharmacologic or adverse effects of that drug. Such occurrences have been reported when propoxyphene was administered to patients on antidepressants, anticonvulsants, or warfarin-like drugs. Severe neurologic signs, including coma have occurred with concurrent use of carbamazepine.

Last reviewed on RxList: 1/29/2005
This monograph has been modified to include the generic and brand name in many instances.