Darvon (Propoxyphene) Patient Information: Missed a Dose and What Should I Avoid at RxList

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May 26, 2012

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Restless Leg Syndrome »

What is restless leg syndrome (RLS)?

Restless leg syndrome (RLS, restless legs syndrome) is a common cause of painful legs. The leg pain of restless leg syndrome typically eases with motion of the legs and becomes more noticeable at rest. Restless leg syndrome also features worsening of symptoms and leg pain during the early evening or later at night.

Restless leg syndrome is often abbreviated RLS; it has also been termed shaking leg syndrome. Nighttime involuntary jerking of the legs during sleep are also known as periodic leg/limb movement disorder.

What causes restless leg syndrome?

The cause of restless leg syndrome is unknown in most people. However, restless leg syndrome has been associated with

pregnancy,
obesity,
smoking,
iron deficiency and anemia,
nerve disease,
polyneuropathy (which can be associated with hypothyroidism, heavy ...

Read the Restless Leg Syndrome article »

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Darvon Patient Information including If I Miss a Dose

What happens if I miss a dose (Darvon)?

Since propoxyphene is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose (Darvon)?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of propoxyphene can be fatal, especially if you are also drinking alcohol or taking a sedative or antidepressant.

Overdose symptoms may include extreme drowsiness, pinpoint or dilated pupils, confusion, cold and clammy skin, blue lips, weak pulse, slow or uneven heart rate, shallow breathing, fainting, or breathing that stops.

What should I avoid while taking propoxyphene (Darvon)?

Do not drink alcohol while you are taking propoxyphene. Dangerous side effects or death can occur when alcohol is combined with a narcotic pain medicine. Check your food and medicine labels to be sure these products do not contain alcohol.

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Grapefruit and grapefruit juice may interact with propoxyphene and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What other drugs will affect propoxyphene (Darvon)?

Do not take propoxyphene with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Before taking this medication, tell your doctor if you are using any of the following drugs:

amiodarone (Cordarone, Pacerone);
aprepitant (Emend);
bosentan (Tracleer);
conivaptan (Vaprisol);
dexamethasone (Decadron, Hexadrol);
imatinib (Gleevec);
isoniazid (for treating tuberculosis);
St. John's wort;
an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), rifampin (Rifadin, Rifater, Rifamate), or telithromycin (Ketek);
antifungal medication such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
an antidepressant such as nefazodone;
a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
a blood thinner such as warfarin (Coumadin);
heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase), or ritonavir (Norvir);
medicines to treat narcolepsy, such as armodafanil (Nuvigil) or modafanil (Progivil); or
seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and there may be other drugs that can interact with propoxyphene. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about propoxyphene.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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