Daypro (Oxaprozin Caplets) Drug Information: Overdosage and Contraindications

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May 27, 2012

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NSAIDs (Nonsteroidal Antiinflammatory Drugs) »

What are NSAIDs and how do they work?

As the class name suggests, nonsteroidal antiinflammatory drugs (NSAIDs) reduce inflammation but are not related to steroids which also reduce inflammation. NSAIDs work by reducing the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever. They also protect the lining of the stomach and intestines from the damaging effects of acid, and promote blood clotting by activating blood platelets. Prostaglandins also affect kidney function.

The enzymes that produce prostaglandins are called cyclooxygenase (COX). There are two types of COX enzymes, COX-1 and COX-2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever; however, only COX-1 produces prostaglandins that activate platelets and protect the stomach and intestinal lining.

NSAIDs block COX enzymes and reduce production of prostaglandins. Therefore, inflammation, pain, and f...

Read the NSAIDs (Nonsteroidal Antiinflammatory Drugs) article »

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OVERDOSE

No patient experienced either an accidental or intentional overdosage of DAYPRO (oxaprozin caplets) in the clinical trials of the drug. Symptoms following acute overdose with other NSAIDs are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain and are generally reversible with supportive care. Gastrointestinal bleeding and coma have occurred following NSAID overdose. Hypertension, acute renal failure, and respiratory depression are rare. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose.

Patients should be managed by symptomatic and supportive care following an NSAID overdose. There are no specific antidotes. Gut decontamination may be indicated in patients seen within 4 hours of ingestion with symptoms or following a large overdose (5 to 10 times the usual dose). This should be accomplished via emesis and/or activated charcoal (60 to 100 g in adults, 1 to 2 g/kg in children) with an osmotic cathartic. Forced diuresis, alkalization of the urine, or hemoperfusion would probably not be useful due to the high degree of protein binding of oxaprozin.

CONTRAINDICATIONS

DAYPRO (oxaprozin caplets) is contraindicated in patients with known hypersensitivity to oxaprozin.

DAYPRO (oxaprozin caplets) should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients (see WARNINGS, Anaphylactoid Reactions and PRECAUTIONS, Preexisting asthma).

DAYPRO (oxaprozin caplets) is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Last reviewed on RxList: 4/17/2008
This monograph has been modified to include the generic and brand name in many instances.