home > drugs a-z list > ddavp nasal spray (desmopressin acetate nasal spray) drug center > ddavp nasal spray (desmopressin acetate nasal spray) drug - overdosage and contraindications

Signs of overdose may include confusion, drowsiness, continuing headache, problems with passing urine and rapid weight gain due to fluid retention. (See WARNINGS.) In case of overdosage, the dose should be reduced, frequency of administration decreased, or the drug withdrawn according to the severity of the condition. There is no known specific antidote for desmopressin acetate or DDAVP Nasal Spray.

An oral LD₅₀ has not been established. An intravenous dose of 2 mg/kg in mice demonstrated no effect.

DDAVP Nasal Spray (desmopressin acetate nasal spray) is contraindicated in individuals with known hypersensitivity to desmopressin acetate or to any of the components of DDAVP Nasal Spray (desmopressin acetate nasal spray) .

DDAVP is contraindicated in patients with moderate to severe renal impairment (defined as a creatinine clearance below 50ml/min).

DDAVP is contraindicated in patients with hyponatremia or a history of hyponatremia.

Last reviewed on RxList: 2/12/2008
This monograph has been modified to include the generic and brand name in many instances.