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DDAVP Nasal Spray

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DDAVP Nasal Spray

DDAVP Nasal Spray

SIDE EFFECTS

Infrequently, high dosages of intranasal DDAVP have produced transient headache and nausea. Nasal congestion, rhinitis and flushing have also been reported occasionally along with mild abdominal cramps. These symptoms disappeared with reduction in dosage. Nosebleed, sore throat, cough and upper respiratory infections have also been reported.

The following table lists the percentage of patients having adverse experiences without regard to relationship to study drug from the pooled pivotal study data for nocturnal enuresis.

ADVERSE REACTION PLACEBO
(N=59)
DDAVP
20 mcg
(N=60)
DDAVP
40 mcg
(N=61)
  % % %
BODY AS A WHOLE
  Abdominal Pain 0 2 2
  Asthenia 0 0 2
  Chills 0 0 2
  Headache 0 2 5
NERVOUS SYSTEM
  Dizziness 0 0 3
RESPIRATORY SYSTEM
  Epistaxis 2 3 0
  Nostril Pain 0 2 0
  Rhinitis 2 8 3
DIGESTIVE SYSTEM
  Gastrointestinal Disorder 0 2 0
  Nausea 0 0 2
SPECIAL SENSES
  Conjunctivitis 0 2 0
  Edema Eyes 0 2 0
  Lachrymation Disorder 0 0 2

Post Marketing: There have been rare reports of hyponatremic convulsions associated with concomitant use with the following medications: oxybutinin and imipramine.

See WARNINGS for the possibility of water intoxication and hyponatremia.

Read the DDAVP Nasal Spray (desmopressin acetate nasal spray) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

Although the pressor activity of DDAVP is very low compared to the antidiuretic activity, use of large doses of intranasal DDAVP with other pressor agents should only be done with careful patient monitoring. The concomitant administration of drugs that may increase the risk of water intoxication with hyponatremia, (e.g. tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, NSAIDs, lamotrigine and carbamazepine) should be performed with caution.

Last reviewed on RxList: 2/12/2008
This monograph has been modified to include the generic and brand name in many instances.

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DDAVP Nasal Spray - User Reviews

DDAVP Nasal Spray User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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