"There is a risk for dosing errors with the dual antibacterial ceftolozane/tazobactam (Zerbaxa, Cubist Pharmaceuticals) due to confusion about the drug strength displayed on the vial and carton labeling, the US Food and Drug Administration "...
(demeclocycline hydrochloride) Tablets, USP For Oral Use
To reduce the development of drug-resistant bacteria and maintain the effectiveness of demeclocycline hydrochloride tablets and other antibacterial drugs, demeclocycline hydrochloride tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Demeclocycline hydrochloride is an antibiotic isolated from a mutant strain of Streptomyces aureofaciens. Chemically it is 7-Chloro-4-(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2naphthacenecarboxamide monohydrochloride. Its structural formula is:
Demeclocycline hydrochloride tablets, USP, for oral administration, contain 150 mg or 300 mg of demeclocycline hydrochloride and the following inactive ingredients: alginic acid, corn starch, D&C Red #7, D&C Yellow #10 Aluminium Lake, ethylcellulose, hypromellose, light mineral oil, magnesium stearate, mineral oil, sodium lauryl sulfate, sorbitol and titanium dioxide.
What are the possible side effects of demeclocycline (Declomycin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using demeclocycline and call your doctor at once if you have a serious side effect such as:
- fever, chills, body aches, flu symptoms;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- pale skin, dark colored urine, jaundice (yellowing of the skin or eyes);
- confusion, mood changes, weakness, increased thirst or...
What are the precautions when taking demeclocycline hcl (Declomycin)?
See also Side Effects section.
Before taking demeclocycline, tell your doctor or pharmacist if you are allergic to it; or to other tetracycline medication (e.g., doxycycline, minocycline, tetracycline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, problems swallowing, esophagus problems (e.g., esophageal ulcers, hiatal hernia, acid reflux disease-GERD), lupus, a certain hormone imbalance called "water diabetes" (diabetes insipidus).
This drug may make you dizzy. Do not drive, use machinery, or do any...
Last reviewed on RxList: 10/22/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Declomycin Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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