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Medical Author: Benjamin C. Wedro, MD, FAAEM
Medical Editor: Melissa Conrad Stöppler, MD
The majority of the body is made up of water, with up to 75% of the body's weight due to H2O. Most of the water is found within the cells of the body (intracellular space). The rest is found in what is referred to as the extracellular space, which consists of the blood vessels (intravascular space) and the spaces between cells (interstitial space).
Total body water = intracellular space + intravascular space + interstitial space
Dehydration occurs when the amount of water leaving the body is greater than the amount being taken in. The body is very dynamic and always changing. This is especially true with water in the body. We lose water routinely when:
In a normal day, a person has to drink a significant amount of water to replace this routine loss.
If intravascular (within the blood vessels) water is lost, the body can compensate somewhat by shifting water from cells into the blood vessels, but this is a very short-term solution. Signs and symptoms of dehydration will occur quickly if the water is not replenished.
The body is able to monitor the amount of fluid it needs to function. The thirst mechanism signals the body to drink water when the body is dry. As well, hormones like anti-diuretic hormone (ADH) work with the kidney to limit the amount of water lost in the urine when the body needs to conserve water.


Dehydration occurs because there is too much water lost, not enough water taken in, or most often a combination of the two.
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