"The US Food and Drug Administration (FDA) has approved tofacitinib citrate extended-release (Xeljanz XR, Pfizer Inc) 11-mg tablets for once-daily treatment of moderate to severe rheumatoid arthritis (RA) in patients who have not responde"...
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Fluid and Electrolyte Disturbances
Loss of muscle mass
Tendon rupture, particularly of the Achilles tendon
Vertebral compression fractures
Aseptic necrosis of femoral and humeral heads
Pathologic fracture of long bones
Peptic ulcer with possible perforation and hemorrhage
Increases in alanine transaminase (ALT, SGPT), aspartate
transaminase (AST, SGOT) and alkaline phosphatase have been observed following corticosteroid treatment. These changes are usually small, not associated with any clinical syndrome and are reversible upon discontinuation.
Development of Cushingoid state
Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness
Suppression of growth in children
Decreased carbohydrate tolerance
Manifestations of latent diabetes mellitus
Increased requirements for insulin or oral hypoglycemic agents in diabetics
Urticaria and other allergic, anaphylactic or hypersensitivity reactions
Read the Deltasone (prednisone) Side Effects Center for a complete guide to possible side effects
The pharmacokinetic interactions listed below are potentially clinically important.
Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin
may increase the clearance of corticosteroids and may require increases in corticosteroid
dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole
may inhibit the metabolism of corticosteroids and thus decrease their clearance.
Therefore, the dose of corticosteroid should be titrated to avoid steroid toxicity.
Corticosteroids may increase the clearance of chronic high dose aspirin. This
could lead to decreased salicylate serum levels or increase the risk of salicylate
toxicity when corticosteroid is withdrawn. Aspirin should be used cautiously
in conjunction with corticosteroids in patients suffering from hypoprothrombinemia.
The effect of corticosteroids on oral anticoagulants is variable. There are
reports of enhanced as well as diminished effects of anticoagulants when given
concurrently with corticosteroids.
Read the Deltasone Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 4/20/2007
Additional Deltasone Information
- Deltasone Drug Interactions Center: prednisone oral
- Deltasone Side Effects Center
- Deltasone Overview including Precautions
- Deltasone FDA Approved Prescribing Information including Dosage
Deltasone - User Reviews
Deltasone User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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