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(Meperidine Hydrochloride) Injection, USP
Meperidine hydrochloride is ethyl 1-methyl-4-phenylisonipecotate hydrochloride, a white crystalline substance with a melting point of 186°C to 189°C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling.
Demerol™ injection is supplied as: Carpuject™ Single-use cartridges with luer lock at concentrations of 25 mg/mL, 50 mg/mL, 75 mg/mL, and 100 mg/mL; Uni-Amp™ unit dose pak-ampuls at concentrations of 25 mg/0.5 mL, 50 mg/mL, 75 mg/1.5 mL, 100 mg/2 mL, and 100 mg/mL; and Multiple-use vials at concentrations of 50 mg/mL (1500 mg/30 mL) and 100 mg/mL (2000 mg/20 mL), which contain metacresol 0.1% as a preservative.
The pH of Demerol™ solutions is adjusted between 3.5 and 6 with sodium hydroxide or hydrochloric acid.
Demerol™, brand of meperidine hydrochloride, 5 percent solution has a specific gravity of 1.0086 at 20°C and 10 percent solution, a specific gravity of 1.0165 at 20°C.
What are the possible side effects of meperidine (Demerol HCl)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- weak or shallow breathing, slow heartbeat;
- severe drowsiness, feeling like you might pass out;
- seizure (convulsions);
- cold, clammy skin;
- muscle movements you cannot control;
- confusion, mood changes;
- severe weakness or dizziness; or
- agitation, hallucinations, fever, fast heart rate,...
What are the precautions when taking meperidine (Demerol)?
Before taking meperidine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before taking this medication, tell your doctor or pharmacist your medical history, especially of: abdominal problems (e.g., gallbladder disease, pancreatitis), adrenal gland problem (e.g., Addison's disease, pheochromocytoma), large blood loss (e.g., recent blood donation, stomach/intestinal bleeding), brain disorders (e.g., seizures, head injury, tumor, increased intracranial pressure), heart problems (e.g., irregular heartbeat, low blood pressure), kidney disease, liver disease, breathing problems (e.g., asthma,...
Last reviewed on RxList: 1/5/2016
This monograph has been modified to include the generic and brand name in many instances.
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